Aoki Yoshiyasu, Tosato Giovanna
Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Semin Hematol. 2003 Apr;40(2):143-53. doi: 10.1053/shem.2003.50014.
Human herpesvirus-8 (HHV-8), a recently discovered oncogenic human virus, is consistently associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). These disorders occur more frequently, but not exclusively, in human immunodeficiency virus (HIV)-infected individuals, and exhibit more aggressive clinical courses when developing in the setting of acquired immunodeficiency syndrome (AIDS). One of the most intriguing aspects of HHV-8-related disorders is the involvement of numerous growth factors in their pathogenesis. This review will focus on several HHV-8 gene products that exhibit proinflammatory and proangiogenic activities or act as transcriptional activators of cellular cytokines that are involved in the pathogenesis of HHV-8-related disorders.
人疱疹病毒8型（HHV-8）是一种最近发现的致癌性人类病毒，与卡波西肉瘤（KS）、原发性渗出性淋巴瘤（PEL）和多中心Castleman病（MCD）始终相关。这些疾病在感染人类免疫缺陷病毒（HIV）的个体中更频繁发生，但并非仅见于此类个体，并且在获得性免疫缺陷综合征（AIDS）背景下发生时表现出更具侵袭性的临床病程。HHV-8相关疾病最引人关注的方面之一是众多生长因子参与其发病机制。本综述将聚焦于几种HHV-8基因产物，这些产物具有促炎和促血管生成活性，或作为参与HHV-8相关疾病发病机制的细胞因子的转录激活因子。
