Cannon M, Cesarman E
Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.
Semin Oncol. 2000 Aug;27(4):409-19.
Kaposi's sarcoma-associated herpes virus (KSHV), also known as human herpes virus-8 (HHV-8), is a recently described gamma-herpes virus that has been etiologically linked to two different acquired immunodeficiency syndrome (AIDS)-related malignancies by strong epidemiologic and pathologic evidence. Infection been shown to precede and predict the development of Kapasi's sarcoma (KS) in human immunodeficiency virus (HIV)-infected patients, and viral DNA has been found in KS lesions of all types and stages. Furthermore, KSHV is a lymphotropic virus and is present in nearly all cases of primary effusion lymphoma, a rare malignancy disproportionately affecting HIV-infected individuals. KSHV is also thought to dramatically affect the incidence, type, and course of multicentric Castleman's disease, another lymphoproliferative disorder over-represented in people with AIDS. KSHV encodes many potentially oncogenic products, including several apparently pirated from the human genome. These include various chemokines, cell cycle regulatory proteins, and survival and proliferation factors. Knowledge is rapidly accumulating concerning the viral pathogenic mechanisms and host cofactors necessary for KSHV-mediated disease.
卡波西肉瘤相关疱疹病毒（KSHV），也称为人类疱疹病毒8型（HHV - 8），是一种最近被描述的γ疱疹病毒，强有力的流行病学和病理学证据已在病因上将其与两种不同的获得性免疫缺陷综合征（AIDS）相关恶性肿瘤联系起来。在人类免疫缺陷病毒（HIV）感染患者中，已证明感染先于卡波西肉瘤（KS）发生并可预测其发展，并且在所有类型和阶段的KS病变中均发现了病毒DNA。此外，KSHV是一种嗜淋巴细胞病毒，几乎在所有原发性渗出性淋巴瘤病例中都存在，原发性渗出性淋巴瘤是一种罕见的恶性肿瘤，在HIV感染个体中不成比例地高发。KSHV还被认为会显著影响多中心Castleman病的发病率、类型和病程，多中心Castleman病是另一种在艾滋病患者中过度出现的淋巴增生性疾病。KSHV编码许多潜在的致癌产物，包括几种明显从人类基因组中盗用的产物。这些产物包括各种趋化因子、细胞周期调节蛋白以及存活和增殖因子。关于KSHV介导疾病所需的病毒致病机制和宿主辅助因子的知识正在迅速积累。
