异烟酰异丙肼和异氯肼的定量气液色谱法。

Quantitative gas-liquid chromatography of iproniazid and iproclozide.

作者信息

de Sagher R M, De Leenheer A P, Claeys A E

出版信息

J Chromatogr Sci. 1976 Jun;14(6):302-8. doi: 10.1093/chromsci/14.6.302.

DOI:10.1093/chromsci/14.6.302

Abstract

Analytically packed columns prepared with Versamid-930, Versamid-900, XE-60, and OV-225 as stationary phases were examined for quantitative gas-liquid chromatography of the potent monamine oxydase inhibitor (MAOI) drugs iproniazid and iproclozide. With the aid of chemically related substances as internal standards, response ratios were determined and linearities calculated by regression analysis. Using the 2-butyl analogs of compounds all four column systems permit quantitation of iproniazid and iproclozide with a percent standard deviation sigmaK of about 1% or less.

摘要

以Versamid - 930、Versamid - 900、XE - 60和OV - 225作为固定相制备的分析填充柱，用于高效单胺氧化酶抑制剂（MAOI）药物异烟肼和异氯肼的定量气相色谱分析。借助化学相关物质作为内标，测定响应比并通过回归分析计算线性关系。使用化合物的2 - 丁基类似物，所有四种柱系统均可对异烟肼和异氯肼进行定量分析，标准偏差百分比sigmaK约为1%或更低。