患有肌营养不良蛋白病的患者表现出氧化应激增加的迹象。
Patients with dystrophinopathy show evidence of increased oxidative stress.
作者信息
Rodriguez M Christine, Tarnopolsky Mark A
机构信息
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
出版信息
Free Radic Biol Med. 2003 May 1;34(9):1217-20. doi: 10.1016/s0891-5849(03)00141-2.
Duchenne muscular dystrophy (DMD) is associated with an increase in oxidative stress. We measured 24 h 8-hydroxy-2'-deoxyguanosine (8-OHdG) excretion in 24 patients with MD (DMD + Becker's MD), 23 with myotonic dystrophy, and 34 healthy controls. The 8-OHdG/creatinine ratio was higher in patients with dystrophinopathy ( upward arrow 48%, p <.01) but not myotonic dystrophy, as compared to healthy controls. These results indicate that 8-OHdG excretion can be used as a marker of oxidative stress in clinical trials with dystrophinopathy.
杜氏肌营养不良症（DMD）与氧化应激增加有关。我们测量了24例肌营养不良症患者（DMD + 贝克型肌营养不良症）、23例强直性肌营养不良症患者和34名健康对照者24小时的8-羟基-2'-脱氧鸟苷（8-OHdG）排泄量。与健康对照者相比，肌营养不良蛋白病患者的8-OHdG/肌酐比值更高（升高48%，p <.01），但强直性肌营养不良症患者则不然。这些结果表明，在肌营养不良蛋白病的临床试验中，8-OHdG排泄可作为氧化应激的标志物。
Zotero 插件