Nagao Masahiro, Kato Shuichi, Hayashi Hideaki, Misawa Hidemi
Department of Neurology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo, Japan.
Acta Neuropathol. 2003 Dec;106(6):557-60. doi: 10.1007/s00401-003-0759-1. Epub 2003 Aug 14.
Synapses on the motor neurons of patients with Duchenne muscular dystrophy (DMD) and myotonic dystrophy (MD) were studied immunohistochemically using antibodies against synaptobrevin and synaptophysin. Some motor neurons showed hyperproliferation of synapses on the soma and the proximal dendrites. Hyperproliferated synapses were non-cholinergic, because they were not identified with antibodies against vesicular acetylcholine transporter. Regeneration of motor nerve terminals in patients with muscular diseases may affect reorganization of the subsets of central synapses.
使用抗突触小泡蛋白和突触素的抗体，通过免疫组织化学方法研究了杜氏肌营养不良症（DMD）和强直性肌营养不良症（MD）患者运动神经元上的突触。一些运动神经元在胞体和近端树突上显示出突触的过度增殖。过度增殖的突触是非胆碱能的，因为它们不能被抗囊泡乙酰胆碱转运体的抗体识别。肌肉疾病患者运动神经末梢的再生可能会影响中枢突触亚群的重组。
