从人血清中分离并初步鉴定与淀粉样蛋白相关的血清淀粉样蛋白A
Isolation and partial characterization of SAA-an amyloid-related protein from human serum.
作者信息
Rosenthal C J, Franklin E C, Frangione B, Greenspan J
出版信息
J Immunol. 1976 May;116(5):1415-8.
PMID:1270801
Abstract
A 12,000 dalton serum amyloid A protein (SAA) has been isolated by chromatography on Sephadex in 10% formic acid. It is similar immunologically to the previously characterized 8500 dalton tissue amyloid A (AA) protein. The results of amino acid analyses, peptide maps, and the identity of the first 11 residues of the SAA and AA proteins support the idea that AA represents the amino terminal fragment of SAA and is derived from it by proteolysis.
摘要
通过在10%甲酸中用葡聚糖凝胶进行层析，已分离出一种12,000道尔顿的血清淀粉样蛋白A（SAA）。它在免疫学上与先前鉴定的8500道尔顿组织淀粉样蛋白A（AA）相似。氨基酸分析、肽图结果以及SAA和AA蛋白前11个残基的一致性支持了这样一种观点，即AA代表SAA的氨基末端片段，是通过蛋白水解从SAA衍生而来的。
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