Bandhu R, Shankar N, Tandon O P
Department of Physiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110 095.
Indian J Physiol Pharmacol. 2003 Jan;47(1):59-66.
Iron deficiency anemia (IDA) in children has been associated with retardation in growth and the cognitive development. In the ongoing study on the effects of IDA in school going children, the effects on anthropometric parameters such as height (Ht), Weight (Wt), head circumference (HC), body mass index (BMI) and the mid arm circumference (MAC) were studied along with the hematological parameters such as hemoglobin (Hb), hematocrit (Hct), MCV, MCH, serum iron (SI), total iron binding capacity (TIBC) and % saturation. The pre-supplementation values of all these parameters were taken in anemic and control groups of girls and boys. After deworming all the children with albendazole (400 mg), the anemic group was put on iron supplementation (Ferrous iron 3-4 mg/kg body weight/day) along with vitamin C (100 mg OD) and the control children were given vitamin C (100 mg OD), for 90 days. Pre-supplementation values of IDA children were significantly lower for MAC and HC in girls and for Ht and MAC in boys, when compared to the control group. After the therapy both the groups of girls showed improvement in the hematological parameters though it was greater in the anemic girls. Ht and Wt of both groups also improved significantly but the anemic girls showed increase in BMI also. Both the control and anemic boys showed gain in weight. Post therapy, improvement in hematological parameters for both the anemic girls and boys were greater than their respective control groups. The MAC value for anemic girls were in the control range but those of anemic boys remained lesser than the control boys. So, it can be concluded from the present study that the IDA children lagged behind the control children in terms of anthropometric parameters and they benefited relatively more in terms of anthropometric improvement and hematological improvement after iron supplementation.
儿童缺铁性贫血(IDA)与生长发育和认知发展迟缓有关。在一项正在进行的关于IDA对学龄儿童影响的研究中,研究了其对身高(Ht)、体重(Wt)、头围(HC)、体重指数(BMI)和上臂围(MAC)等人体测量参数的影响,同时还研究了血红蛋白(Hb)、血细胞比容(Hct)、平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、血清铁(SI)、总铁结合力(TIBC)和饱和度百分比等血液学参数。在贫血组和对照组的女孩和男孩中获取了所有这些参数的补充前值。在用阿苯达唑(400毫克)对所有儿童进行驱虫后,贫血组儿童开始补充铁剂(硫酸亚铁3 - 4毫克/千克体重/天)并同时补充维生素C(100毫克,每日一次),而对照组儿童仅给予维生素C(100毫克,每日一次),持续90天。与对照组相比,IDA儿童补充前的MAC和HC值在女孩中显著较低,在男孩中Ht和MAC值显著较低。治疗后,两组女孩的血液学参数均有改善,不过贫血女孩的改善更为明显。两组的Ht和Wt也显著改善,但贫血女孩的BMI也有所增加。对照组和贫血组男孩的体重均有所增加。治疗后,贫血女孩和男孩的血液学参数改善均大于各自的对照组。贫血女孩的MAC值处于对照范围内,但贫血男孩的MAC值仍低于对照男孩。因此,从本研究可以得出结论,IDA儿童在人体测量参数方面落后于对照儿童,并且在补充铁剂后,他们在人体测量改善和血液学改善方面相对受益更多。