Bandhu R, Shankar N, Tandon O P, Madan N
Department of Physiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110 095.
Indian J Physiol Pharmacol. 2003 Jul;47(3):301-10.
The present study was conducted on 18 anemic and 34 control subjects (mean age 9.26 +/- 0.26 years) to observe the effect of anemia on cognition and to see effect of 3 months of iron therapy on it. Anemia was defined on the basis of hematological values and peripheral smear examinations. Cognitive data consisted of the recording of the P300 wave of Auditory Event Related Potentials (AERP), Ravens Progressive Matrices Test (RPMT), and Digit Span Attention Test (DSAT) under standard test conditions. RPMT scores were then converted to the intelligence quotient (IQ) scores for comparison. Both anemic and control boys were dewormed after recording pretreatment values and then anemic boys were given iron therapy for 3 months, after which the recordings were taken again. Pretreatment, anemic boys showed significantly lower hematological values, delayed P300 latency, and lower RPMT scores as compared to controls. Post therapy the hematological profile of anemic boys though significantly improved as compared to the pretreatment values, was still significantly lower than that of control boys. The P300 latency values of anemic boys showed improvement but were still significantly delayed than the control group. RPMT values and derived IQ scores of anemic boys were similar to control boys after therapy suggesting that though the 3 months iron therapy regime resulted in improvement in psychometric cognitive tests in anemic boys, the basic P300 defects persisted. This suggests that the P300 component of AERP in anemic children is relatively refractory to 3 months of iron therapy.
本研究对18名贫血儿童和34名对照儿童（平均年龄9.26±0.26岁）进行，以观察贫血对认知的影响，并观察3个月铁剂治疗对其的影响。贫血根据血液学指标和外周血涂片检查来定义。认知数据包括在标准测试条件下记录听觉事件相关电位（AERP）的P300波、瑞文渐进性矩阵测验（RPMT）和数字广度注意力测验（DSAT）。然后将RPMT分数转换为智商（IQ）分数进行比较。在记录预处理值后，对贫血男孩和对照男孩都进行了驱虫，然后对贫血男孩进行3个月的铁剂治疗，之后再次进行记录。预处理时，与对照组相比，贫血男孩的血液学指标显著更低，P300潜伏期延迟，RPMT分数更低。治疗后，贫血男孩的血液学指标虽然与预处理值相比有显著改善，但仍显著低于对照男孩。贫血男孩的P300潜伏期值有所改善，但仍比对照组显著延迟。治疗后贫血男孩的RPMT值和推导的IQ分数与对照男孩相似，这表明尽管3个月的铁剂治疗方案使贫血男孩的心理测量认知测试有所改善，但基本的P300缺陷仍然存在。这表明贫血儿童AERP的P300成分对3个月的铁剂治疗相对难治。
