Murúa Roberto, Navarrete Maritza, Cádiz Rodrigo, Figueroa Rodolfo, Padula Paula, Zaror Luis, Mansilla Rita, González Luz, Muñoz-Pedreros Andrés
Convenio Reservorio Hantavirus, Universidad Austral de Chile y Servicio de Salud de Valdivia.
Rev Med Chil. 2003 Feb;131(2):169-76.
In Chile, three Hantavirus seropositive rodent species (O longicaudatus, A olivaceus and A longipilis) are distributed from the Pacific coast to the Andes mountains and represent nearly 90% of the rodents captured in the Xth Region.
To study the seroprevalence of Hantavirus among captured rodent species and its relationship with the appearance of human cases of pulmonary syndrome.
From May 1998 to September 2001, 675 rodents were captured in the region. Serum samples were tested by ELISA for the presence of IgG antibodies against Andes and Sin Nombre virus. Sera from human cases with a suspected Hantavirus infection were analyzed for IgM antibodies against Black Lagoon virus and for IgG antibodies against Andes and Sin Nombre virus.
Twenty two of the 675 rodents were seropositive for the virus, 18 O longicaudatus and 4 A longipilis. Regional seroprevalence changed from 2.2% in 1998, 0.0% in 1999, 1.0% in 2000 and up to 7.1% in 2001. A total of 77 positive human cases were studied from 1998 to March 2002. Although there were positive cases in all seasons, data showed a spring-summer seasonal preponderance. A relationship between the flowering of "colihue" bushes and the increased values of rodent abundance, seroprevalence and positive animals was established.
A dispersal movement of O longicaudatus to open habitats close to human outdoor activities during the dry season was confirmed.
在智利，三种汉坦病毒血清阳性啮齿动物物种（长尾稻鼠、橄榄稻鼠和长须稻鼠）分布于从太平洋沿岸到安第斯山脉的区域，占第十大区捕获啮齿动物的近90%。
研究捕获啮齿动物物种中汉坦病毒的血清阳性率及其与人类肺综合征病例出现的关系。
1998年5月至2001年9月，在该地区捕获了675只啮齿动物。通过酶联免疫吸附测定法检测血清样本中抗安第斯病毒和辛诺柏病毒的IgG抗体。对疑似感染汉坦病毒的人类病例血清进行分析，检测抗黑湖病毒的IgM抗体以及抗安第斯病毒和辛诺柏病毒的IgG抗体。
675只啮齿动物中有22只为病毒血清阳性，其中18只为长尾稻鼠，4只为长须稻鼠。区域血清阳性率从1998年的2.2%、1999年的0.0%、2000年的1.0%变化至2001年的7.1%。1998年至2002年3月共研究了77例阳性人类病例。虽然所有季节均有阳性病例，但数据显示春夏季节占优势。确定了“colihue”灌木丛开花与啮齿动物数量增加、血清阳性率及阳性动物数量增加之间的关系。
证实了长尾稻鼠在旱季向靠近人类户外活动的开阔栖息地扩散的移动情况。
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