Zak-Nejmark Teresa, Passowicz-Muszyńska Ewa, Jankowska Renata
Klinika Chorób Wewnetrznych i Alergologii AM we Wrocławiu.
Pneumonol Alergol Pol. 2002;70(9-10):478-82.
In 16 patients with lung cancer submitted to radical surgery skin reactivity was studied. Skin prick test was done in all patients with histamine concentration--10 mg/ml and negative control before and after surgery. The longest wheal diameter was measured after 15 min and 30 min. The wheal size was determined as a difference between histamine wheal diameter and negative control diameter (before surgery--after 15 min. 1.53 +/- 1.43 mm., after 30 min. 2.31 +/- 1.77 mm. vs after surgery--after 15 min 3.44 +/- 1.06; p < 0.001, after 30 min 4.25 +/- 1.20; p < 0.001. In patients with lung cancer the significant increase in histamine wheal size was observed as compared with its size before surgery. The lower expression of histamine wheal receptors (mainly H1 skin receptors) is probably caused by cancer suppression. The expression of these receptors increased after tumor excision.
对16例行根治性手术的肺癌患者的皮肤反应性进行了研究。对所有患者在手术前后进行组胺浓度为10mg/ml的皮肤点刺试验及阴性对照。15分钟和30分钟后测量最长风团直径。风团大小通过组胺风团直径与阴性对照直径之差确定（术前——15分钟后1.53±1.43mm，30分钟后2.31±1.77mm；术后——15分钟后3.44±1.06；p<0.001，30分钟后4.25±1.20；p<0.001）。与术前相比，肺癌患者组胺风团大小显著增加。组胺风团受体（主要是H1皮肤受体）表达降低可能是由癌症抑制所致。肿瘤切除后这些受体的表达增加。
