Bengtsson B O S, Wootton-Gorges S L, Poulain F R, Sherman M P
Division of Neonatology, Department of Pediatrics, Section of Pediatric Radiology, University of California, Davis, CA 95616, USA.
Acta Paediatr. 2003;92(2):251-3. doi: 10.1111/j.1651-2227.2003.tb00536.x.
To describe the association between morphine administration in preterm infants, hydronephrosis, and renal dysfunction.
The findings were based on serial ultrasound examinations and blood studies.
Two preterm infants had bladder distension and hydronephrosis after they received intravenous morphine for analgesia. Morphine was used at a low dose. Each patient had a normal urine output and normal serum creatinine before the signs and symptoms of urinary retention were observed. Within 24 h of morphine administration, each infant concurrently developed oliguria and elevation of the serum creatinine. Cessation of morphine and urinary drainage resulted in rapid and complete resolution of the hydronephrosis and the elevated creatinine.
Morphine, even at low dosages, can be associated with hydronephrosis in hospitalized preterm infants.
描述早产儿使用吗啡与肾积水及肾功能障碍之间的关联。
研究结果基于系列超声检查和血液研究。
两名早产儿在接受静脉注射吗啡镇痛后出现膀胱扩张和肾积水。吗啡使用剂量较低。在观察到尿潴留的体征和症状之前，每名患者的尿量和血清肌酐均正常。在使用吗啡的24小时内，每名婴儿同时出现少尿和血清肌酐升高。停用吗啡并进行尿液引流后，肾积水和升高的肌酐迅速且完全消退。
即使是低剂量的吗啡，也可能与住院早产儿的肾积水有关。
