Rogol A D, Kahn C R
J Pediatr. 1976 Jun;88(6):953-8. doi: 10.1016/s0022-3476(76)81048-7.
A growth-retarded, mentally deficient, young man is described with diminished secretory response of growth hormone, thyrotropin, and prolactin to the pharmacologic stimuli of insulin, arginine, chlorpromazine, and thyrotropin-releasing hormone. Gonadotropin and ACTH functions were normal both basically and upon pharmacologic stimulation. Additionally, the patient was unresponsive to exogenous thyrotropin injections. These data suggest that the hypothyroidism in this patient was due to combined thyroid dysgenesis and pituitary insufficiency, i.e., primary and secondary hypothyroidism.
描述了一名生长发育迟缓、智力缺陷的年轻男子，其生长激素、促甲状腺激素和催乳素对胰岛素、精氨酸、氯丙嗪和促甲状腺激素释放激素的药理刺激的分泌反应减弱。促性腺激素和促肾上腺皮质激素功能在基础状态和药理刺激下均正常。此外，该患者对外源性促甲状腺激素注射无反应。这些数据表明，该患者的甲状腺功能减退是由于甲状腺发育不全和垂体功能不全共同导致的，即原发性和继发性甲状腺功能减退。
