通过最大程度手术切除恶性胶质瘤优化治疗结果。
Optimizing outcomes with maximal surgical resection of malignant gliomas.
作者信息
Hentschel Stephen J, Sawaya Raymond
机构信息
Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
出版信息
Cancer Control. 2003 Mar-Apr;10(2):109-14. doi: 10.1177/107327480301000202.
BACKGROUND
Aggressive surgical resection of malignant gliomas is a controversial issue in neurosurgery. Studies with rigorous methodology that fully address this issue have only recently become available.
METHODS
The controversy regarding the role of maximal surgical resection of malignant gliomas is reviewed. The authors discuss surgical techniques and adjunctive technologies that can be utilized to assist in resection of these lesions.
RESULTS
Using current microneurosurgical techniques, it is possible to resect malignant gliomas in gross total fashion. An aggressive approach in which 98% or more of the tumor mass is resected results in a statistically significant survival advantage.
CONCLUSIONS
An aggressive surgical procedure for malignant gliomas can result in increased survival duration for selected groups of patients.
背景
恶性胶质瘤的积极手术切除在神经外科领域是一个有争议的问题。采用严格方法并全面解决此问题的研究直到最近才出现。
方法
回顾了关于恶性胶质瘤最大程度手术切除作用的争议。作者讨论了可用于辅助切除这些病变的手术技术和辅助技术。
结果
使用当前的显微神经外科技术，有可能以大体全切的方式切除恶性胶质瘤。采用积极的方法，即切除98%或更多的肿瘤组织，在统计学上可带来显著的生存优势。
结论
对于特定患者群体，积极的恶性胶质瘤手术可延长生存期。
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