Bertoni Bernardo, Budowle Bruce, Sans Mónica, Barton Sara A, Chakraborty Ranajit
Departamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
Hum Biol. 2003 Feb;75(1):1-11. doi: 10.1353/hub.2003.0016.
The effect of gene flow on Hispanic populations from different geographic regions of the United States was analyzed using six autosomal DNA markers (LDLR, GYPA, HBGG, D7S8, GC, and HLA-DQA). By region of sampling, the Hispanic populations showed different ancestry contributions, from a trihybrid structure with European, Native American, and African contributions (California, Nevada, Florida, New Jersey, and Virginia) to a dihybrid structure with European and American contributions (Southwest population) or European and African contributions (Pennsylvania and Southeast population). These findings allowed us to define two regional groups, the West and the East. In the former, Native American contributions ranged from 35.58% to 57.87%; in the East region the values ranged from 0% to 21.27%. An African influence was similar in both regions, ranging from 0% to 17.11%, with a tendency of increasing in the East region. These data reflect the different origins of the Hispanic populations that led to the present ones. In the West, Hispanics are mostly of Mexican origin, and in the East, they are predominantly of Cuban and Puerto Rican origin.
使用六个常染色体DNA标记（低密度脂蛋白受体基因LDLR、血型糖蛋白A基因GYPA、β-珠蛋白基因HBGG、D7S8、维生素D结合蛋白基因GC和人类白细胞抗原-DQA基因HLA-DQA）分析了基因流动对来自美国不同地理区域的西班牙裔人群的影响。按采样地区划分，西班牙裔人群显示出不同的祖先贡献，从具有欧洲、美洲原住民和非洲贡献的三杂交结构（加利福尼亚州、内华达州、佛罗里达州、新泽西州和弗吉尼亚州）到具有欧洲和美洲贡献的双杂交结构（西南部人群）或欧洲和非洲贡献的双杂交结构（宾夕法尼亚州和东南部人群）。这些发现使我们能够定义两个区域组，即西部和东部。在前者中，美洲原住民的贡献范围为35.58%至57.87%；在东部地区，该值范围为0%至21.27%。非洲的影响在两个区域相似，范围为0%至17.11%，在东部地区有增加的趋势。这些数据反映了导致现在西班牙裔人群的不同起源。在西部，西班牙裔大多起源于墨西哥，而在东部，他们主要起源于古巴和波多黎各。
