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Asymmetric synthesis of the four possible fagomine isomers.

作者信息

Takahata Hiroki, Banba Yasunori, Ouchi Hidekazu, Nemoto Hideo, Kato Atsushi, Adachi Isao

机构信息

Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.

出版信息

J Org Chem. 2003 May 2;68(9):3603-7. doi: 10.1021/jo034137u.

DOI:10.1021/jo034137u
PMID:12713367
Abstract

The asymmetric synthesis of fagomine and its congeners 1-4 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the d-serine-derived Garner aldehyde 6.

摘要

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