Schrittwieser Joerg H, Resch Verena
Department of Biotechnology , Delft University of Technology , Julianalaan 136 , 2628 BL Delft , The Netherlands . Email:
RSC Adv. 2013 Oct 21;3(39):17602-17632. doi: 10.1039/c3ra42123f. Epub 2013 Aug 7.
Alkaloids are not only one of the most intensively studied classes of natural products, their wide spectrum of pharmacological activities also makes them indispensable drug ingredients in both traditional and modern medicine. Among the methods for their production, biotechnological approaches are gaining importance, and biocatalysis has emerged as an essential tool in this context. A number of chemo-enzymatic strategies for alkaloid synthesis have been developed over the years, in which the biotransformations nowadays take an increasingly 'central' role. This review summarises different applications of biocatalysis in the asymmetric synthesis of alkaloids and discusses how recent developments and novel enzymes render innovative and efficient chemo-enzymatic production routes possible.
生物碱不仅是研究最为深入的天然产物类别之一，其广泛的药理活性还使其成为传统医学和现代医学中不可或缺的药物成分。在生物碱的生产方法中，生物技术方法正变得越来越重要，而生物催化在这一背景下已成为一种关键工具。多年来已开发出许多用于生物碱合成的化学酶法策略，如今生物转化在其中发挥着越来越“核心”的作用。本综述总结了生物催化在生物碱不对称合成中的不同应用，并讨论了近期的进展和新型酶如何使创新且高效的化学酶法生产路线成为可能。
