Denko C W, Whitehouse M W
J Rheumatol. 1976 Mar;3(1):54-62.
Inflammation caused by insoluble microcrystalline calcium salts was compared with inflammation elicited by soluble carrageenan and monosodium urate crystals, in rats' paws. Local and systemic responses to four calcium crystals, viz. pyrophosphate, triphosphate, oxalate, and tartrate were studied. Changes in liver function, reflected in reduced serum albumin and increased sleep times in response to barbiturates, indicative of systemic inflammation, occurred despite the localized nature of the crystal induced inflammation. Serum thiol levels were also reduced. These altered functions were similar to, but less pronounced than, those accompanying the severe systemic inflammation produced by Freund's adjuvant. A copper glycine complex was effective in reducing foot swelling due to triphosphate, and edema due to oxalate. Colchicine had very little effect on the inflammation caused by the insoluble calcium salts but inhibited inflammation due to sodium urats crystals and soluble carrageenan. Crystal-induced inflammation that is outwardly localized may induce biochemical changes that are similar to changes found in systemic inflammation.
在大鼠爪部，将不溶性微晶钙盐引起的炎症与可溶性角叉菜胶和尿酸钠晶体引发的炎症进行了比较。研究了对四种钙晶体，即焦磷酸盐、三磷酸盐、草酸盐和酒石酸盐的局部和全身反应。尽管晶体诱导的炎症具有局部性，但仍出现了肝功能变化，表现为血清白蛋白降低以及对巴比妥类药物的睡眠时间增加，这表明存在全身炎症。血清硫醇水平也降低了。这些功能改变与弗氏佐剂引起的严重全身炎症所伴随的改变相似，但程度较轻。一种铜甘氨酸复合物可有效减轻由三磷酸盐引起的足部肿胀以及草酸盐引起的水肿。秋水仙碱对不溶性钙盐引起的炎症几乎没有作用，但可抑制尿酸钠晶体和可溶性角叉菜胶引起的炎症。表面上局部化的晶体诱导炎症可能会引发与全身炎症中发现的变化相似的生化变化。
