Pussinen Pirkko J, Jousilahti Pekka, Alfthan Georg, Palosuo Timo, Asikainen Sirkka, Salomaa Veikko
Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland.
Arterioscler Thromb Vasc Biol. 2003 Jul 1;23(7):1250-4. doi: 10.1161/01.ATV.0000072969.71452.87. Epub 2003 Apr 24.
We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis.
CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050).
In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.
我们通过测定血清中抗伴放线放线杆菌和牙龈卟啉单胞菌的IgG抗体，分析了一个随机抽取的45至74岁男性样本（n = 1163）中冠心病（CHD）与牙周炎血清学之间的关联。
冠心病（n = 159）在无牙受试者中比有牙受试者更为普遍（分别为19.8%和12.1%，P = 0.003）。在有牙人群中，牙龈卟啉单胞菌血清阳性的受试者患冠心病的比例高于血清阴性者（分别为14.0%和9.7%，P = 0.029）。因此，联合抗体反应高的受试者患冠心病的比例高于反应低的受试者（分别为17.4%和11.1%，P = 0.026）。在对年龄和多个冠心病危险因素进行校正后，联合抗体反应高的受试者患现患冠心病的比值比为1.5（95%可信区间，0.95至2.50，P = 0.077）。在一个线性回归模型中，联合抗体反应与现患冠心病直接相关（P = 0.046），与血清高密度脂蛋白胆固醇浓度呈负相关（P = 0.050）。
总之，无牙状态和针对主要牙周病原体的血清抗体与冠心病有关。这表明牙周感染或宿主对感染的反应可能在冠心病的发病机制中起作用。
