Yang Zhe-Yu, Fang Wen-Hui, Kao Chia-Chun, Chen Wei-Liang
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, School of Medicine, Taipei, Taiwan.
National Defense Medical Center, School of Medicine, Taipei, Taiwan.
Front Med (Lausanne). 2022 Jul 22;9:899063. doi: 10.3389/fmed.2022.899063. eCollection 2022.
This investigation explored the relationship between oral bacteria and metabolic syndrome (METS).
There were 4,882 subjects enrolled in this cross-sectional study from the NHANES III database. The severity of periodontitis was classified into mild, moderate and severe. We measured oral bacterial antibodies. We examined the relationship between serum immunoglobulin G (IgG) antibodies of oral bacteria and METS performing multivariate regression analysis. Mediation analysis of oral bacteria on the correlation between periodontitis and METS was also executed.
After adjusting for covariates, the serum IgG antibodies of , and were associated with the presence of METS ( = 0.006, = 0.014 and = 0.018, respectively). Furthermore, serum IgG antibodies of and were positively associated with the presence of METS ( = 0.001, = 0.011, and = 0.002, respectively) and ≥4 features of METS ( = 0.019, = 0.025, and = 0.02, respectively). IgG mediated 11.2% of the relationship between periodontitis and METS.
Serological markers of oral pathogens were correlated with the presence and the number of METS features after multivariable adjustment. Oral bacteria acted as a mediator of the correlation between periodontitis and METS. Our study provided a biologically plausible explanation for the association between periodontitis and METS, which provides a comprehensive evaluation of periodontitis.
本研究探讨口腔细菌与代谢综合征（METS）之间的关系。
本横断面研究从美国国家健康与营养检查调查（NHANES）III数据库中纳入了4882名受试者。牙周炎的严重程度分为轻度、中度和重度。我们测量了口腔细菌抗体。通过多变量回归分析，研究口腔细菌的血清免疫球蛋白G（IgG）抗体与METS之间的关系。还对口腔细菌在牙周炎与METS相关性中的中介作用进行了分析。
在调整协变量后，[具体细菌名称1]、[具体细菌名称2]和[具体细菌名称3]的血清IgG抗体与METS的存在相关（分别为P = 0.006、P = 0.014和P = 0.018）。此外，[具体细菌名称4]和[具体细菌名称5]的血清IgG抗体与METS的存在呈正相关（分别为P = 0.001、P = 0.011和P = 0.002）以及与METS的≥4项特征呈正相关（分别为P = 0.019、P = 0.025和P = 0.02）。IgG介导了牙周炎与METS之间11.2%的关系。
在多变量调整后，口腔病原体的血清学标志物与METS特征的存在及数量相关。口腔细菌在牙周炎与METS的相关性中起中介作用。我们的研究为牙周炎与METS之间的关联提供了生物学上合理的解释，这为牙周炎提供了全面评估。
