Gimenez Andréa, Limongi João Carlos Papaterra, Valente Anna Carolina Tavares, Gimenez Cristiane, da Silva Jair Urbano
Médicina Residente de Clínica Médica do Hospital Ipiranga, São Paulo, SP, Brasil.
Arq Neuropsiquiatr. 2003 Mar;61(1):121-4. doi: 10.1590/s0004-282x2003000100025. Epub 2003 Apr 16.
Leptomeningeal carcinomatosis is a neurological complication of several systemic tumors and is characterized by multifocal invasion of the meninges by neoplastic cells. It is estimated that 5% of all patients with cancer will present leptomeningeal carcinomatosis at some time during the course of the illness. Clinical manifestations are heterogeneous and present with signs and symptoms related to involvement of multiple areas of the nervous system, particularly cranial nerves and spinal roots. The diagnosis is based on suggestive clinical findings, cerebrospinal fluid (CSF) testing and imaging studies. The most informative findings come from CSF where the presence of neoplastic cells is definitive for the diagnosis. The purpose of this report is to describe, along with a review of the literature, a clinical case of a 42 years old man in whom the first clinical signs of a lung cancer manifested with symptoms suggestive of meningeal involvement.
柔脑膜癌病是几种全身性肿瘤的神经并发症，其特征是肿瘤细胞对脑膜的多灶性侵犯。据估计，所有癌症患者中有5%会在病程中的某个时候出现柔脑膜癌病。临床表现多种多样，表现为与神经系统多个区域受累相关的体征和症状，尤其是脑神经和脊神经根。诊断基于提示性的临床发现、脑脊液（CSF）检测和影像学检查。最具诊断价值的发现来自脑脊液，其中肿瘤细胞的存在对诊断具有决定性意义。本报告的目的是结合文献复习，描述一名42岁男性的临床病例，该患者肺癌的首发临床症状提示脑膜受累。
