Rangarajan Meera, Zatz Joel L
Organon USA, 375 Mt. Pleasant Avenue, West Orange, NJ 07052, USA.
J Cosmet Sci. 2003 Mar-Apr;54(2):161-74.
The objective of this research was to investigate the effect of concentration and delivery system on skin permeation of alpha-tocopherol (alpha-T). Also, the addition of sunscreens and oleic acid on alpha-T permeation was studied using an in vitro micro-Yucatan pig skin model. Various delivery systems of alpha-T (1%) were formulated, which included simple solution, gels, emulsions, and microemulsions. The experimental design chosen for this study was a statistical randomized complete block design. alpha-T delivery was proportional to its concentration. The hydroalcoholic gel delivered significantly higher amounts of alpha-T into the receptor than the other gels used. A microemulsion containing isopropyl myristate emerged as the best delivery system for alpha-T among all the systems studied. Pig skin is a suitable in vitro model for studying the permeation of alpha-T and possibly other antioxidants, though in vivo experiments in humans are required to further corroborate the data.
本研究的目的是调查浓度和给药系统对α-生育酚（α-T）皮肤渗透的影响。此外，还使用体外尤卡坦微型猪皮肤模型研究了添加防晒剂和油酸对α-T渗透的影响。制备了α-T（1%）的各种给药系统，包括简单溶液、凝胶、乳液和微乳液。本研究选择的实验设计是统计随机完全区组设计。α-T的给药量与其浓度成正比。与其他使用的凝胶相比，水醇凝胶向受体中递送的α-T量显著更高。在所研究 的所有系统中，含有肉豆蔻酸异丙酯的微乳液成为α-T的最佳给药系统。猪皮是研究α-T以及可能其他抗氧化剂渗透的合适体外模型，不过需要在人体进行体内实验以进一步证实这些数据。
