Institute of Biomedical Science, University of São Paulo, São Paulo 05508, SP, Brazil.
Pharmaceutics. 2014 Feb 28;6(1):52-77. doi: 10.3390/pharmaceutics6010052.
Microemulsions are fluid and isotropic formulations that have been widely studied as delivery systems for a variety of routes, including the skin. In spite of what the name suggests, microemulsions are nanocarriers, and their use as topical delivery systems derives from their multiple advantages compared to other dermatological formulations, such as ease of preparation, thermodynamic stability and penetration-enhancing properties. Composition, charge and internal structure have been reported as determinant factors for the modulation of drug release and cutaneous and transdermal transport. This manuscript aims at reviewing how these and other characteristics affect delivery and make microemulsions appealing for topical and transdermal administration, as well as how they can be modulated during the formulation design to improve the potential and efficacy of the final system.
微乳液是一种流体各向同性的制剂，已被广泛研究作为各种途径的递药系统，包括皮肤。尽管微乳液的名称表明了它们的性质，但实际上它们是纳米载体，其作为局部递药系统的用途源自与其他皮肤科制剂相比的多种优势，例如易于制备、热力学稳定性和增强渗透性能。已经报道了组成、电荷和内部结构是调节药物释放以及皮肤和经皮转运的决定因素。本文旨在综述这些和其他特性如何影响递药，使微乳液成为局部和经皮给药的有吸引力的制剂，以及在制剂设计过程中如何对其进行调节，以提高最终系统的潜力和疗效。
