Cheung Oi Yee, Muhm J R, Helmers R A, Aubry Marie-Christine, Tazelaar Henry D, Khoor Andras, Leslie Kevin O, Colby Thomas V
Department of Pathology and Laboratory Medicine, Mayo Clinic, Scottsdale, AZ 85259, USA.
Ann Diagn Pathol. 2003 Apr;7(2):127-38. doi: 10.1053/adpa.2003.50018.
Agranulomatous interstitial pneumonia is a form of diffuse lung disease in which granulomas are a component of the histologic findings. The differential diagnosis is quite broad, but most cases represent examples of either sarcoidosis, diffuse granulomatous infections, or hypersensitivity pneumonitis. "Hot tub lung" is a recently described form of granulomatous interstitial pneumonia that appears to have some features of diffuse infections and some features of hypersensitivity pneumonitis. The pathologist's approach to these conditions can be facilitated by giving careful attention to the anatomic distribution of the granulomas, the qualitative features of the granulomas, and the histologic changes in the lung tissue around and away from the granulomas. These features, along with the results of cultures and special stains for micro-organisms and clinical and radiologic correlation allow for a diagnosis in the vast majority of cases.
非肉芽肿性间质性肺炎是弥漫性肺疾病的一种形式，在其组织学表现中肉芽肿是一个组成部分。鉴别诊断范围相当广泛，但大多数病例为结节病、弥漫性肉芽肿感染或过敏性肺炎的实例。“热水浴缸肺”是最近描述的一种肉芽肿性间质性肺炎形式，似乎具有弥漫性感染的一些特征和过敏性肺炎的一些特征。通过仔细关注肉芽肿的解剖分布、肉芽肿的定性特征以及肉芽肿周围和远离肉芽肿的肺组织的组织学变化，病理学家对这些病症的诊断方法可得到促进。这些特征，连同微生物培养结果、特殊染色以及临床和放射学相关性，在绝大多数病例中都能做出诊断。
