Gudmundsdóttir Thorbjörg, Tryggvadóttir Laufey, Allende Maria, Mast Thomas Christopher, Briem Haraldur, Sigurdsson Kristián
The Icelandic Directorate of Health, Division of Infectious Disease Control, Reykjavik, Iceland.
Acta Obstet Gynecol Scand. 2003 Apr;82(4):345-50.
Cervical cancer is an important health problem worldwide, and the incidence of preinvasive cervical cancer is increasing among young sexually active women. The causal association between human papilloma virus (HPV) and cervical cancer makes it theoretically possible to eradicate the disease through vaccination. The aim of this study was to analyze the eligibility and willingness of 18-23-year-old Icelandic women to participate in a vaccination trial to prevent HPV infection and to assess knowledge of HPV.
A questionnaire was formulated with questions on demographics, HPV knowledge, sexual behavior, attitude towards HPV vaccination, and other health-related issues. The questionnaire was tested on a subgroup of women before being mailed to 300 women aged 18-23 years, randomly selected by date of birth from the total population living in the Capital area of Reykjavík.
The response rate of the mailed questionnaire was 54%. Of respondents, 96% reported having had sexual debut and 39% were aged 15 years or younger at first intercourse. Knowledge of HPV infections and associated diseases was limited, indicating the need for an educational campaign. Although 60% of the respondents were willing to participate in a HPV vaccination trial, the eligibility rate for the invited women was estimated to be approximately 13% (95% CI: 9-17%) after accounting for various exclusion criteria such as number of sexual partners, abnormal Pap smears, planning a pregnancy, or travelling abroad for more than 6 months.
Icelandic women between 18 and 23 years of age have a sexual behavior profile and lifestyle that may decrease their eligibility in future prophylactic HPV vaccine trials. Improved education about HPV infection and its consequences is needed. Future trials may need to include younger women to improve recruitment.
宫颈癌是全球重要的健康问题，宫颈浸润前癌在年轻性活跃女性中的发病率呈上升趋势。人乳头瘤病毒（HPV）与宫颈癌之间的因果关联使得通过接种疫苗根除该疾病在理论上成为可能。本研究的目的是分析18至23岁冰岛女性参与预防HPV感染疫苗试验的资格和意愿，并评估她们对HPV的了解情况。
制定了一份问卷，内容涉及人口统计学、HPV知识、性行为、对HPV疫苗接种的态度以及其他与健康相关的问题。在将问卷邮寄给从雷克雅未克首都地区总人口中按出生日期随机选取的300名18至23岁女性之前，先在一组女性亚群体中进行了测试。
邮寄问卷的回复率为54%。在受访者中，96%报告有初次性行为，39%初次性交时年龄为15岁或更小。对HPV感染及相关疾病的了解有限，表明需要开展教育活动。尽管60%的受访者愿意参与HPV疫苗试验，但在考虑了诸如性伴侣数量、巴氏涂片异常、计划怀孕或出国旅行超过6个月等各种排除标准后，受邀女性的符合资格率估计约为13%（95%置信区间：9 - 17%）。
18至23岁的冰岛女性具有的性行为特征和生活方式可能会降低她们未来参与预防性HPV疫苗试验的资格。需要加强对HPV感染及其后果的教育。未来的试验可能需要纳入更年轻的女性以改善招募情况。
