Hanel Birgitte, Law Ian, Mortensen Jann
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark.
J Appl Physiol (1985). 2003 Sep;95(3):1076-82. doi: 10.1152/japplphysiol.00082.2002. Epub 2003 Apr 25.
The purpose of the study was to evaluate the effects of maximal exercise on the integrity of the alveolar epithelial membrane using the clearance rate of aerosolized 99mTc-labeled diethylenetriaminepentaacetic acid as an index for the permeability of the lung blood-gas barrier. Ten elite rowers (24.3 +/- 4.6 yr of age) completed two 20-min pulmonary clearance measurements immediately after and 2 h after 6 min of all-out rowing (initial and late, respectively). All subjects participated in resting control measurements on a separate day. For each 20-min measurement, lung clearance was calculated for 0-7 and 10-20 min. Furthermore, scintigrams were processed from the initial and late measurements of diethylenetriaminepentaacetic acid clearance. Compared with control levels, the pulmonary clearance measurement after rowing was increased from 1.2 +/- 0.5 to 2.4 +/- 1.0%/min (SD) at 0-7 min (P < 0.01) and from 0.8 +/- 0.3 to 1.5 +/- 0.4%/min at 10-20 min (P < 0.0005), returning to resting levels within 2 h. In 6 of 10 subjects, ventilation distribution on the lung scintigrams was inhomogeneous at the initial measurement. The study demonstrates an acute increased pulmonary clearance after maximal rowing. The ventilation defects identified on the lung scintigrams may represent transient interstitial edema secondary to increased blood-gas barrier permeability induced by mechanical stress.
本研究的目的是使用雾化的99mTc标记的二乙三胺五乙酸清除率作为肺气血屏障通透性的指标，评估最大运动对肺泡上皮膜完整性的影响。10名精英赛艇运动员（年龄24.3±4.6岁）在全力划船6分钟后立即（分别为初始和后期）以及2小时后完成了两次20分钟的肺清除率测量。所有受试者在另一天进行了静息对照测量。对于每次20分钟的测量，计算0至7分钟和10至20分钟的肺清除率。此外，对二乙三胺五乙酸清除率的初始和后期测量进行了闪烁扫描处理。与对照水平相比，划船后的肺清除率测量在0至7分钟时从1.2±0.5增加到2.4±1.0%/分钟（标准差）（P<0.01），在10至20分钟时从0.8±0.3增加到1.5±0.4%/分钟（P<0.0005），并在2小时内恢复到静息水平。在10名受试者中的6名中，肺闪烁扫描的初始测量时通气分布不均匀。该研究表明最大划船后肺清除率急性增加。肺闪烁扫描上识别出的通气缺陷可能代表机械应力引起的气血屏障通透性增加继发的短暂性间质性水肿。
