Tamai Yoshiko, Takami Hideki
First Department of Internal Medicine, Hirosaki University School of Medicine.
Nihon Rinsho. 2003 Apr;61(4):581-6.
In this article, we refer to thrombocytopenia caused by increased destruction/consumption of platelets(immune thrombocytopenia and non-immune thrombocytopenia), abnormal pooling, and dilutional loss. The cause of idiopathic thrombocytopenic purpura (ITP) is a accelerated platelet destruction due to autoimmune mechanism. Differential diagnosis is important between ITP and other thrombocytopenic disorders, because the treatment and prognosis are distinct. Drug-induced thrombocytopenia is the most common among secondary autoimmune thrombocytopenia and clinically important. The immediate cessation of all suspect drugs is necessary when drug-induced thrombocytopenia is suspected. Thrombocytopenia of disseminated intravascular coagulation(DIC) and thrombotic microangiopathy(TMA) occur in diffuse intravascular coagulation and induce thrombocytopenia by the consumption of the platelet.
在本文中，我们提及由血小板破坏/消耗增加（免疫性血小板减少症和非免疫性血小板减少症）、异常聚集及稀释性丢失所导致的血小板减少症。特发性血小板减少性紫癜（ITP）的病因是由于自身免疫机制导致血小板加速破坏。ITP与其他血小板减少性疾病之间的鉴别诊断很重要，因为治疗方法和预后有所不同。药物性血小板减少症是继发性自身免疫性血小板减少症中最常见且具有临床重要性的。当怀疑为药物性血小板减少症时，必须立即停用所有可疑药物。弥散性血管内凝血（DIC）和血栓性微血管病（TMA）的血小板减少症发生于弥散性血管内凝血过程中，并通过消耗血小板而导致血小板减少。
