Ghazal A, Makar A B, Islam S I
Pharmazie. 1975 Sep;30(9):606-8.
The effect of a series of steroid hormones on the pentetrazol convulsing action, hexobarbital narcotic action and hepatic drug metabolizing enzyme activities was determined in rats. All steroid compounds used antagonized the pentetrazol effect: the most potent was cortisone and the least potent testosterone. Glucocorticoids and androgens shortened the hexobarbital sleeping time and increased the hepatic drug metabolizing enzyme activity. Estradiol exhibited the opposite effect, whereas progesterone and desoxycorticosterone did not affect these two parameters.
测定了一系列甾体激素对大鼠戊四氮惊厥作用、己巴比妥麻醉作用及肝脏药物代谢酶活性的影响。所用的所有甾体化合物均拮抗戊四氮的作用：作用最强的是可的松，最弱的是睾酮。糖皮质激素和雄激素缩短了己巴比妥的睡眠时间，并提高了肝脏药物代谢酶的活性。雌二醇表现出相反的作用，而孕酮和脱氧皮质酮对这两个参数没有影响。
