Hamajima Nobuyuki, Takezaki Toshiro, Matsuo Keitaro, Saito Toshiko, Inoue Manami, Hirai Takashi, Kato Tomoyuki, Ozeki Junko, Tajima Kazuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
Asian Pac J Cancer Prev. 2001;2(1):57-62.
Cyclooxygenase 2 (COX2) is an inducible enzyme synthesizing prostaglandins from arachidonic acid, which is thought to play an important role in colorectal carcinogenesis. Since the COX2 polymorphisms, if functional, may modify the carcinogenesis pathway, the associations between the reported polymorphisms and colorectal cancer risk were examined in a hospital-based case-control study. Six polymorphisms of the gene encoding COX2 were genotyped for 241 non-cancer individuals (controls) and 148 colorectal cancer patients (74 colon cancer, 73 rectal cancer, and 1 colorectal cancer date, 22 polymorphisms including the above six have been reported for COX2. The other polymorphisms remain to be examined.
环氧化酶2（COX2）是一种可诱导的酶，它能从花生四烯酸合成前列腺素，被认为在结直肠癌发生过程中起重要作用。由于COX2基因多态性若具有功能，可能会改变致癌途径，因此在一项基于医院的病例对照研究中，对已报道的多态性与结直肠癌风险之间的关联进行了研究。对241名非癌症个体（对照组）和148名结直肠癌患者（74例结肠癌、73例直肠癌和1例结直肠癌日期）的COX2编码基因的6种多态性进行了基因分型。COX2已报道有22种多态性，包括上述6种。其他多态性仍有待研究。
