前列腺穿刺活检的处理与报告指南。
Guidelines for processing and reporting of prostatic needle biopsies.
作者信息
van der Kwast Th H, Lopes C, Santonja C, Pihl C-G, Neetens I, Martikainen P, Di Lollo S, Bubendorf L, Hoedemaeker R F
机构信息
Department of Pathology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands.
出版信息
J Clin Pathol. 2003 May;56(5):336-40. doi: 10.1136/jcp.56.5.336.
The reported detection rate of prostate cancer, lesions suspicious for cancer, and prostatic intraepithelial neoplasia (PIN) in needle biopsies is highly variable. In part, technical factors, including the quality of the biopsies, the tissue processing, and histopathological reporting, may account for these differences. It has been thought that standardisation of tissue processing might reduce the observed variations in detection rate. Consensus among the members of the pathology committee of the European Randomised study of Screening for Prostate Cancer (ERSPC) concerning the optimal methodology of tissue embedding resulting in guidelines for prostatic needle biopsy processing was reached. The adoption of an unequivocal and uniform way of reporting lesions encountered in prostatic needle biopsies is considered helpful for decision taking by the clinician. The definition of parameters for quality control of prostatic needle biopsy diagnostics will further facilitate clinical epidemiological multicentre studies of prostate cancer.
据报告，针吸活检中前列腺癌、可疑癌病变及前列腺上皮内瘤变（PIN）的检出率差异很大。部分技术因素，包括活检质量、组织处理及组织病理学报告，可能导致了这些差异。人们认为，组织处理的标准化可能会减少观察到的检出率差异。欧洲前列腺癌筛查随机研究（ERSPC）病理委员会成员就组织包埋的最佳方法达成了共识，从而形成了前列腺针吸活检处理指南。采用明确统一的方式报告前列腺针吸活检中遇到的病变，被认为有助于临床医生做出决策。前列腺针吸活检诊断质量控制参数的定义将进一步推动前列腺癌的临床流行病学多中心研究。
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