Lang C J G, Moser F
Neurological Hospital, Friedrich-Alexander-University at Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany.
Arch Womens Ment Health. 2003 Apr;6(2):139-45. doi: 10.1007/s00737-003-0166-6.
It is still a matter of debate whether there are differences between men and women concerning the localization of higher cerebral functions. To further elucidate this problem we conjointly evaluated the aphasia protocols and corresponding computer-assisted tomography (CT) scans of 49 men and 35 women who presented with unilateral ischemic cerebral lesions. Both, the aphasia tests and CT scans, were fed into computer programs warranting a high degree of objectivity. Comparing the four main aphasic syndromes we found differences for each of them displaying a more posterior extension of lesions with global and amnestic aphasia in men and larger lesions with Broca and Wernicke aphasia in women. When all templates were compared, men displayed a wider extension within the left hemisphere than women whose lesions were more focused in the perisylvian area. This study confirms earlier findings claiming that aphasic men and women differ regarding the anterior-posterior extension and the frequency of lesions within the classical language zones. However, while the predominance of men's lesions in the posterior areas was in accordance with previous findings, the greater overall scatter within the left hemisphere contradicts published studies.
关于大脑高级功能定位在男性和女性之间是否存在差异，这仍然是一个有争议的问题。为了进一步阐明这个问题，我们联合评估了49名男性和35名患有单侧缺血性脑损伤的女性的失语症记录及相应的计算机断层扫描（CT）图像。失语症测试和CT扫描都被输入到保证高度客观性的计算机程序中。比较四种主要的失语症综合征时，我们发现每种综合征都存在差异，男性的完全性失语和遗忘性失语的病变显示出更向后延伸，而女性的布罗卡失语和韦尼克失语的病变更大。当比较所有模板时，男性在左半球内的病变延伸范围比女性更广，女性的病变更集中在外侧裂周围区域。这项研究证实了早期的研究结果，即失语症男性和女性在经典语言区域内病变的前后延伸和频率方面存在差异。然而，虽然男性病变在后部区域占优势与先前的研究结果一致，但左半球内更大的总体离散度与已发表的研究相矛盾。
