Metter E J, Wasterlain C G, Kuhl D E, Hanson W R, Phelps M E
Ann Neurol. 1981 Aug;10(2):173-83. doi: 10.1002/ana.410100208.
Positron emission computed tomography (PECT) using 18F-2-fluoro-2-deoxy-D-glucose (FDG) was used to investigate the correlations between clinical status, anatomy (as described by CT), and metabolism in five patients with stable aphasia resulting from ischemic cerebral infarction. Local cerebral metabolic activity was diminished in an area larger than the area of infarction demonstrated by CT. In one patient, FDG PECT revealed a metabolic lesion that probably caused the aphasic syndrome and was not apparent by CT. The data suggest that reliance on CT in delineating the extent of the brain lesion in aphasia or other neuropsychological defects can be misleading; FDG PECT may provide important additional information. Two patients with similar metabolic lesions had very different clinical syndromes, showing that even when currently available methods are combined, major gaps remain in clinicoanatomical correlations in aphasia.
使用18F - 2 - 氟 - 2 - 脱氧 - D - 葡萄糖（FDG）的正电子发射计算机断层扫描（PECT）用于研究5例因缺血性脑梗死导致失语症稳定的患者的临床状态、解剖结构（如CT所示）和代谢之间的相关性。局部脑代谢活动在一个比CT显示的梗死区域更大的区域中减弱。在一名患者中，FDG PECT显示出一个可能导致失语综合征的代谢病变，而CT未显示。数据表明，在描绘失语症或其他神经心理缺陷中的脑损伤范围时依赖CT可能会产生误导；FDG PECT可能提供重要的额外信息。两名具有相似代谢病变的患者有非常不同的临床综合征，表明即使结合目前可用的方法，失语症的临床解剖学相关性仍存在重大差距。
