Wypych Karol, Kuźlik Rafał, Wypych Paweł
Katedry i Kliniki Połoznictwa i Ginekologii II Wydziału Lekarskiego, Akademii Medycznej w Warszawie.
Ginekol Pol. 2002 Nov;73(11):1117-25.
Increased estrogen activity and prolactin hypersecretion is a hormonal reason for Benign Breast Diseases.
To evaluate hormonal disorders in women with gross breast cysts.
30 women with gross breast cysts (over 10 mm in diameter) have been investigated. Cytohormonal vaginal swabs and serum levels of prolactin, estradiol and gonadotropins were evaluated.
Normal prolactin levels were found in 96.7% of cases, but in 8 women with recurrent breast cysts after repeated FNA-biopsies prolactin secretion stimulated by metoclopramide was significantly increased. Low progesterone activity in all women and low estrogen activity in 65.3% were shown. Absolute high estrogen activity was diagnosed only in 8.7% women with gross breast cysts.
Nearly all patients with gross breast cysts have normal prolactin and low progesterone levels. High estrogen levels appear very seldom and in most cases these patients are hypoestrogenic.
雌激素活性增加和催乳素分泌过多是良性乳腺疾病的激素原因。
评估患有巨大乳腺囊肿的女性的激素紊乱情况。
对30名患有巨大乳腺囊肿（直径超过10毫米）的女性进行了调查。评估了细胞激素阴道拭子以及催乳素、雌二醇和促性腺激素的血清水平。
96.7%的病例催乳素水平正常，但在8名经反复细针穿刺活检后出现复发性乳腺囊肿的女性中，胃复安刺激的催乳素分泌显著增加。所有女性均表现出孕酮活性低，65.3%的女性雌激素活性低。仅8.7%患有巨大乳腺囊肿的女性被诊断为绝对高雌激素活性。
几乎所有患有巨大乳腺囊肿的患者催乳素水平正常且孕酮水平低。高雌激素水平很少出现，在大多数情况下这些患者雌激素水平低下。
