Hirohata Shunsei, Kikuchi Hirotoshi
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Arthritis Res Ther. 2003;5(3):139-46. doi: 10.1186/ar757. Epub 2003 Apr 2.
Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required.
白塞病的特征为复发性口腔溃疡、葡萄膜炎、生殖器溃疡和皮肤病变。近年来，HLA - B*51基因的作用已得到证实，尽管据估计其对白塞病总体遗传易感性的贡献仅为19%。已表明，被多种抗原激活的T细胞产生的多种细胞因子在中性粒细胞的激活中起关键作用。关于治疗，抗肿瘤坏死因子α疗法已被证明对黏膜皮肤症状以及威胁视力的全葡萄膜炎有效，不过仍需要进行随机对照试验。
