Atalay Ayfer, Yildiz-Demirtepe Sanem, Tatlipinar Sinan, Sanli-Erdoğan Berna, Cobankara Veli, Yildirim Cem, Bağci Hüseyin, Atalay Erol Omer
Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey.
Mol Biol Rep. 2008 Sep;35(3):345-9. doi: 10.1007/s11033-007-9092-4. Epub 2007 Jun 27.
Behçet's Disease (BD) is a multisystemic inflammatory disorder as a triad of symptoms including recurrent oral and genital aphthous ulceration, and uveitis with unknown pathogenesis. Many researchers have tried to investigate the association of HLA-B51 gene with the BD. We aimed to investigate the association of the HLA-B51 gene and its expression, also polymorphic structure by PCR, RT-PCR and sequence specific oligonucleotide primers and probes in BD patients (n: 35) and control group (n: 50). According to our results, we did not observe any association in between HLA-B51 gene, its polymorphism, expression and BD patients.
白塞病（BD）是一种多系统炎症性疾病，其症状三联征包括复发性口腔和生殖器阿弗他溃疡以及病因不明的葡萄膜炎。许多研究人员试图研究HLA - B51基因与白塞病的关联。我们旨在通过聚合酶链反应（PCR）、逆转录聚合酶链反应（RT - PCR）以及序列特异性寡核苷酸引物和探针，研究BD患者（n = 35）和对照组（n = 50）中HLA - B51基因及其表达以及多态性结构。根据我们的结果，我们未观察到HLA - B51基因及其多态性、表达与BD患者之间存在任何关联。
