生物钟：起搏器与肿瘤抑制因子

The circadian clock: pacemaker and tumour suppressor.

作者信息

Fu Loning, Lee Cheng Chi

机构信息

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

出版信息

Nat Rev Cancer. 2003 May;3(5):350-61. doi: 10.1038/nrc1072.

DOI:10.1038/nrc1072

PMID:12724733

Abstract

The circadian rhythms are daily oscillations in various biological processes that are regulated by an endogenous clock. Disruption of these rhythms has been associated with cancer in humans. One of the cellular processes that is regulated by circadian rhythm is cell proliferation, which often shows asynchrony between normal and malignant tissues. This asynchrony highlights the importance of the circadian clock in tumour suppression in vivo and is one of the theoretical foundations for cancer chronotherapy. Investigation of the mechanisms by which the circadian clock controls cell proliferation and other cellular functions might lead to new therapeutic targets.

摘要

昼夜节律是由内源性生物钟调节的各种生物过程中的每日振荡。这些节律的破坏与人类癌症有关。昼夜节律调节的细胞过程之一是细胞增殖，正常组织和恶性组织之间的细胞增殖往往表现出不同步。这种不同步突出了生物钟在体内肿瘤抑制中的重要性，是癌症时辰疗法的理论基础之一。研究生物钟控制细胞增殖和其他细胞功能的机制可能会带来新的治疗靶点。