Shi A, Wang D, Wang X, Xu X
Prevention & Health Center of Yizheng Chemical Fibre Group Corporetion, Yizheng 211900, China.
Wei Sheng Yan Jiu. 2000 Mar 30;29(2):71-2.
The contents of phospholipids in the lung surfactant in bronchoalveolar lavage fluid(BALF) of rats inhaled terephthalic acid (TPA) dust were analysed with high pressure liquid chromatography (HPLC). The average geometric concentrations of TPA dust in experimental groups were 8.93, 274.45 and 618.12 mg/m3 respectively. The results showed that phosphatidylcholine(PC), phosphatidyl glycerol(PG), and phosphatidylinositol(PI) of the rats exposed to TPA at the middle and high concentrations were decreased as compared with those in the control (P < 0.001). It was suggested that the functions of producing and secreting pulmonary surfactant in type II epithelial cells were damaged after inhalating TPA dust.
采用高压液相色谱法（HPLC）分析吸入对苯二甲酸（TPA）粉尘的大鼠支气管肺泡灌洗液（BALF）中肺表面活性物质的磷脂含量。实验组TPA粉尘的平均几何浓度分别为8.93、274.45和618.12mg/m³。结果显示，中、高浓度TPA染毒大鼠的磷脂酰胆碱（PC）、磷脂酰甘油（PG）和磷脂酰肌醇（PI）含量较对照组降低（P<0.001）。提示吸入TPA粉尘后Ⅱ型上皮细胞产生和分泌肺表面活性物质的功能受损。
