氨溴索对博来霉素诱导的大鼠肺表面活性物质磷脂成分变化的影响。
The effect of Ambroxol on bleomycin-induced changes in phospholipid composition of rat lung surfactant.
作者信息
Stettner S, Ledwozyw A
机构信息
I Clinic of General Surgery, Medical Academy, Lublin, Poland.
出版信息
Acta Physiol Hung. 1995;83(2):181-7.
The influence of Ambroxol on bleomycin-induced changes in lung surfactant phospholipid composition in rats was examined. Bleomycin alone (intratracheally 10 mg/kg, single dose) produces a significant fall in phosphatidylcholine (especially in disaturated species) and phosphatidylglicerol content in both lavage and postlavaged lung tissues surfactants. Ambroxol (8 days, 2 mg/kg s.c. per day) normalizes these changes. Thus, Ambroxol has an salutary effect on bleomycin-induced changes in lung surfactant phospholipids.
研究了氨溴索对博来霉素诱导的大鼠肺表面活性物质磷脂成分变化的影响。单独使用博来霉素（气管内注射10mg/kg，单次剂量）可使灌洗和灌洗后肺组织表面活性物质中的磷脂酰胆碱（尤其是二饱和磷脂酰胆碱）和磷脂酰甘油含量显著下降。氨溴索（8天，每天皮下注射2mg/kg）可使这些变化恢复正常。因此，氨溴索对博来霉素诱导的肺表面活性物质磷脂变化具有有益作用。
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