Zhu H, Wang S, Xu Y, Chen Y
Faculty of Clinic Nutrition, School of Public Health, SUMS, Guangzhou 510089, China.
Wei Sheng Yan Jiu. 2000 Mar 30;29(2):104-5.
To investigate the disorder of lipid metabolism and explore the possible mechanism of increasing risk of atherosclerosis(AS) in simple childhood obesity, serum lipids and apolipoprotein were examined. 49 obese children were selected and another 49 non-obese children were selected as control. Their serum lipids (TG, TC, VLDL-ch, HDL-ch and LDL-ch) and apolipoprotein(apoA1 and apoB100) were measured. The results showed TG, VLDL-ch, apoB100, artherosclerosis index (AI) and LDL-ch/HDL-ch ratio in childhood obesity were significantly higher than that in normal children (P < 0.05), while HDL-ch, apoA1, HDL-ch/TC, apoA1/apoB100 ratio in obese children were obviously lower than that in normal ones(P < 0.05). The results suggested that metabolic disorder of lipid and apolipoprotein took place in obese children. The disorder which may increase the risk of AS should be paid great attention.
为研究单纯性儿童肥胖症患者脂质代谢紊乱情况并探讨动脉粥样硬化（AS）风险增加的可能机制，对血清脂质和载脂蛋白进行了检测。选取49例肥胖儿童，并选取另外49例非肥胖儿童作为对照。检测他们的血清脂质（甘油三酯、总胆固醇、极低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇）和载脂蛋白（载脂蛋白A1和载脂蛋白B100）。结果显示，儿童肥胖症患者的甘油三酯、极低密度脂蛋白胆固醇、载脂蛋白B100、动脉粥样硬化指数（AI）和低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值显著高于正常儿童（P<0.05），而肥胖儿童的高密度脂蛋白胆固醇、载脂蛋白A1、高密度脂蛋白胆固醇/总胆固醇、载脂蛋白A1/载脂蛋白B100比值明显低于正常儿童（P<0.05）。结果提示，肥胖儿童存在脂质和载脂蛋白代谢紊乱。这种可能增加AS风险的紊乱应予以高度关注。
