Magarò M, Altomonte L, Zoli A, Mirone L, Ruffini M P
Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
Z Rheumatol. 1991 May-Jun;50(3):168-70.
Cardiovascular diseases and atherosclerotic manifestations have been reported to be the most common causes of death in rheumatoid arthritis (RA). In the present investigation the levels of serum lipids, apolipoproteins (A1 and B100), total proteins, and albumin were studied in 35 female patients affected by active RA. Apolipoproteins A1 and B100 were significantly lower in RA patients than in controls. No significant difference was observed in total cholesterol, LDL cholesterol, or triglycerides. In contrast, HDL cholesterol and serum albumin were significantly lower in RA patients compared to controls. The finding of reduced apolipoproteins and HDL-cholesterol levels may represent an important factor in the etiology of cardiovascular and atherosclerotic disease in RA. Reduced levels of albumin in active RA may indicate a reduced rate of proteins like lipoproteins in the liver.
据报道，心血管疾病和动脉粥样硬化表现是类风湿关节炎（RA）最常见的死亡原因。在本研究中，对35名患有活动性RA的女性患者的血脂、载脂蛋白（A1和B100）、总蛋白和白蛋白水平进行了研究。RA患者的载脂蛋白A1和B100明显低于对照组。总胆固醇、低密度脂蛋白胆固醇或甘油三酯未观察到显著差异。相比之下，RA患者的高密度脂蛋白胆固醇和血清白蛋白明显低于对照组。载脂蛋白和高密度脂蛋白胆固醇水平降低的发现可能是RA中心血管和动脉粥样硬化疾病病因的一个重要因素。活动性RA中白蛋白水平降低可能表明肝脏中脂蛋白等蛋白质的生成率降低。
