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[免疫分期与化疗反应之间的相关性。64例不可切除的支气管表皮样癌患者的结果]

[Correlation between immunological stage and response to chemotherapy. Results in 64 patients with nonresectable epidermoid bronchial cancers].

作者信息

Pouillart P, Botto G, Gauthier H, Huguenin P, Baron A, Laparre C, Hoang Thy H T, Parrot R, Mathé G

出版信息

Nouv Presse Med. 1976 Apr 17;5(16):1037-42.

PMID:1272771
Abstract

Out of 64 patients with non resectable epidermal bronchus carcinoma, 26 patients had before any treatment positive responses of skin tests to recall antigens. In these patients we found a correlation between the reactivity of the skin tests, the presence of seric factor inhibiting the leucocyte migration, the mean count of peripheral lymphocytes and the response to combination chemotherapy protocol. The patients who respond to treatment have a significantly better prognosis than the patients who do not respond. With this correlation it seems to be possible to distinguish between two populations of patients with non resectable bronchus carcinoma : one population with a good risk who can be significantly improved by the treatment : the other population with a very severe prognosis.

摘要

在64例不可切除的表皮型支气管癌患者中,26例患者在任何治疗之前皮肤试验对回忆抗原呈阳性反应。在这些患者中,我们发现皮肤试验的反应性、抑制白细胞迁移的血清因子的存在、外周淋巴细胞的平均计数与联合化疗方案的反应之间存在相关性。对治疗有反应的患者预后明显好于无反应的患者。基于这种相关性,似乎有可能区分不可切除支气管癌的两类患者:一类风险较低,治疗可使其显著改善;另一类预后极差。

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