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孕前狂饮与意外怀孕风险:对女性及其子女的影响

Binge drinking in the preconception period and the risk of unintended pregnancy: implications for women and their children.

作者信息

Naimi Timothy S, Lipscomb Leslie E, Brewer Robert D, Gilbert Brenda Colley

机构信息

Alcohol Team, Emerging Investigations and Analytic Methods Branch, Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.

出版信息

Pediatrics. 2003 May;111(5 Pt 2):1136-41.

Abstract

OBJECTIVE

To assess the relationship between unintended pregnancy resulting in a live birth and binge drinking (having 5 or more alcoholic beverages on 1 occasion) in the 3 months before pregnancy (the preconception period) and to characterize women who are of childbearing age and binge drink.

METHODS

A case-control study was conducted of women with pregnancies that resulted in a live birth, comparing those with unintended pregnancies with those with intended pregnancies. Data analyzed were from the 15 states that participated in the Pregnancy Risk Assessment Monitoring System from 1996-1999.

RESULTS

Of 72 907 respondents, 45% of pregnancies were unintended. Compared with women with intended pregnancy, women with unintended pregnancy were more likely to be young and black and to report preconception binge drinking (16.3% vs 11.9%; odds ratio [OR]: 1.43; 95% confidence interval [CI]: 1.13-1.54). After adjusting for potential confounders, preconception binge drinking was associated with unintended pregnancy for white women (adjusted OR: 1.63; 95% CI: 1.47-1.80) but not for black women (adjusted OR: 0.96, 95% CI: 0.77-1.20). Overall, 14% of women reported preconception binge drinking. Women who binge drank in the preconception period were more likely to be white and unmarried; to smoke and be exposed to violence in the preconception period; and to consume alcohol, binge drink, and smoke during pregnancy.

CONCLUSIONS

Binge drinking in the preconception period was associated with unintended pregnancies resulting in a live birth among white women but not among black women. Preconception binge drinkers were more likely to engage in other risky behaviors, including drinking during pregnancy. Comprehensive interventions to reduce binge drinking may reduce unintended pregnancies, as well as other adverse maternal and pediatric health outcomes.

摘要

目的

评估孕前3个月(受孕前期)意外妊娠并活产与暴饮(一次饮用5杯或更多酒精饮料)之间的关系,并描述育龄期暴饮女性的特征。

方法

对活产妊娠女性进行病例对照研究,将意外妊娠女性与计划妊娠女性进行比较。分析的数据来自1996 - 1999年参与妊娠风险评估监测系统的15个州。

结果

在72907名受访者中,45%的妊娠为意外妊娠。与计划妊娠女性相比,意外妊娠女性更可能年轻、为黑人,且报告受孕前期有暴饮情况(16.3%对11.9%;优势比[OR]:1.43;95%置信区间[CI]:1.13 - 1.54)。在对潜在混杂因素进行调整后,受孕前期暴饮与白人女性的意外妊娠相关(调整后OR:1.63;95% CI:1.47 - 1.80),但与黑人女性无关(调整后OR:0.96,95% CI:0.77 - 1.20)。总体而言,14%的女性报告受孕前期有暴饮情况。受孕前期暴饮的女性更可能为白人、未婚;在受孕前期吸烟且遭受暴力;在孕期饮酒、暴饮和吸烟。

结论

受孕前期暴饮与白人女性意外妊娠并活产相关,但与黑人女性无关。受孕前期暴饮者更可能从事其他危险行为,包括孕期饮酒。减少暴饮的综合干预措施可能会减少意外妊娠以及其他不良的母婴和儿童健康结局。

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