1997 - 2000年美国使用辅助生殖技术受孕的多胞胎趋势。

Trends in multiple births conceived using assisted reproductive technology, United States, 1997-2000.

作者信息

Reynolds Meredith A, Schieve Laura A, Martin Joyce A, Jeng Gary, Macaluso Maurizio

机构信息

Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3717, USA.

出版信息

Pediatrics. 2003 May;111(5 Pt 2):1159-62.

PMID:12728130

Abstract

OBJECTIVE

To examine trends in multiple births conceived using assisted reproductive technology (ART) in the United States between 1997 and 2000 and to estimate the proportion of all US multiple births attributable to ART use.

METHODS

We analyzed population-based data of 109 519 live-born infants who were conceived in the United States using ART and born between 1997 and 2000 and population-based data of 15 856 809 live-born infants who were delivered in the United States between 1997 and 2000. Multiple birth rates (the number of live-born infants delivered in multiple gestation pregnancies per 1000 live births) and the proportion of all US multiple births attributable to ART were evaluated.

RESULTS

The twin rate for ART patients increased between 1997 and 2000, reaching 444.7 per 1000 live births in 2000, whereas the triplet/+ rate declined substantially from 134.3 to 98.7 per 1000 live births from 1997-2000. From 1997-2000, the proportion of multiple births in the United States attributable to ART increased from 11.2% to 13.6%, whereas the proportion attributable to natural conception decreased from 69.9% to 64.5%. In 2000, the proportion of triplet/+ births attributable to ART and to natural conception was 42.5% and 17.7%, respectively. The contribution of ART to multiple births increased substantially with maternal age, from 11.6% for triplet/+ infants born to women aged 20 to 24 to 92.8% for women aged 45 to 49 years.

CONCLUSIONS

The contribution of ART to twin birth rates continues to increase, but the contribution of ART to triplet/+ birth rates has declined.

摘要

目的

研究1997年至2000年间美国使用辅助生殖技术（ART）受孕的多胞胎趋势，并估算美国所有多胞胎中因使用ART所致的比例。

方法

我们分析了1997年至2000年间在美国使用ART受孕并出生的109519例活产婴儿的基于人群的数据，以及1997年至2000年间在美国分娩的15856809例活产婴儿的基于人群的数据。评估了多胞胎出生率（每1000例活产中多胎妊娠分娩的活产婴儿数）以及美国所有多胞胎中因ART所致的比例。

结果

1997年至2000年间，ART患者的双胞胎率有所上升，2000年达到每1000例活产444.7例，而三胞胎及以上出生率从1997年至2000年从每1000例活产134.3例大幅下降至98.7例。1997年至2000年，美国因ART所致的多胞胎比例从11.2%增至13.6%，而因自然受孕所致的比例从69.9%降至64.5%。2000年，因ART和自然受孕所致的三胞胎及以上出生率分别为42.5%和17.7%。ART对多胞胎的贡献随产妇年龄大幅增加，从20至24岁妇女所生三胞胎及以上婴儿的11.6%增至45至49岁妇女所生婴儿的92.8%。