实验小鼠模型对人类糖尿病的启示。
Lessons for human diabetes from experimental mouse models.
作者信息
Kulkarni Rohit N, Zisman Ariel
机构信息
Joslin Diabetes Center, One Joslin Place, Room 602, Boston, MA 02215, USA.
出版信息
Curr Diab Rep. 2003 Apr;3(2):168-75. doi: 10.1007/s11892-003-0041-x.
PMID:12728643
Abstract
A precise knowledge of the defects underlying type 1 and type 2 diabetes is essential for designing appropriate therapeutic strategies. Because experiments in humans are limited, naturally occurring, and especially genetically engineered rodent models, have revolutionized research in diabetes. We review some of the models created recently and discuss their impact on human diabetes.
摘要
精确了解1型和2型糖尿病潜在的缺陷对于设计合适的治疗策略至关重要。由于人体实验有限，自然发生的，尤其是基因工程改造的啮齿动物模型，彻底改变了糖尿病研究。我们回顾了一些最近创建的模型，并讨论了它们对人类糖尿病的影响。
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