Section of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA.
Cell Metab. 2013 Dec 3;18(6):775-91. doi: 10.1016/j.cmet.2013.08.010. Epub 2013 Sep 12.
The landmark discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka has transformed regenerative biology. Previously, insights into the pathogenesis of chronic human diseases have been hindered by the inaccessibility of patient samples. However, scientists are now able to convert patient fibroblasts into iPSCs and differentiate them into disease-relevant cell types. This ability opens new avenues for investigating disease pathogenesis and designing novel treatments. In this review, we highlight the uses of human iPSCs to uncover the underlying causes and pathological consequences of diabetes and metabolic syndromes, multifactorial diseases whose etiologies have been difficult to unravel using traditional methodologies.
山中伸弥（Shinya Yamanaka）发现诱导多能干细胞（iPSCs）这一具有里程碑意义的发现改变了再生生物学。在此之前，由于无法获得患者样本，慢性人类疾病发病机制的相关研究受到阻碍。然而，科学家现在能够将患者成纤维细胞转化为 iPSCs，并将其分化为与疾病相关的细胞类型。这种能力为研究疾病发病机制和设计新型治疗方法开辟了新途径。在这篇综述中，我们强调了使用人类 iPSCs 来揭示糖尿病和代谢综合征等多因素疾病的潜在病因和病理后果，这些疾病的病因用传统方法很难阐明。
