卡介苗第一剂和第二剂接种的不良反应发生率：巴西学童大型社区试验的结果
Rates of adverse reactions to first and second doses of BCG vaccination: results of a large community trial in Brazilian schoolchildren.
作者信息
Dourado I, Rios M H, Pereira S M M, Cunha S S, Ichihara M Y, Goes J C L, Rodrigues L C, Bierrenbach A L, Barreto M L
机构信息
Instituto de Saúde Coletiva/Universidade Federal da Bahia, Salvador, Bahia.
出版信息
Int J Tuberc Lung Dis. 2003 Apr;7(4):399-402.
OBJECTIVE
To evaluate the incidence of adverse reactions to first and second bacille Calmette-Guérin (BCG) vaccination in schoolchildren.
SETTING AND DESIGN
Enhanced surveillance in a Brazilian trial. Suspected reactions were reported to a nurse who visited cases and completed a standard form.
RESULTS
Among 71341 schoolchildren studied, 33 reactions were reported. Of these, 25 fulfilled the criteria, resulting in a rate of one per 2854 vaccinations, with no deaths or BCG-osis. Reactions to second doses were more common than to first BCG vaccinations, but this difference was not statistically significant.
CONCLUSIONS
Adverse reactions to a second dose of BCG may be more frequent than reactions to a first dose, but they are still rare events.
目的
评估学龄儿童首次和第二次卡介苗（BCG）接种不良反应的发生率。
背景与设计
巴西一项试验中的强化监测。疑似反应报告给一名护士，该护士访视病例并填写标准表格。
结果
在研究的71341名学龄儿童中，报告了33例反应。其中25例符合标准，导致每2854次接种中有1例发生反应，无死亡或卡介苗病。第二次接种的反应比首次卡介苗接种更常见，但这种差异无统计学意义。
结论
第二剂卡介苗的不良反应可能比第一剂更频繁，但仍然是罕见事件。
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