• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

卡介苗接种后老年个体抗菌肽反应增强

Enhanced Antimicrobial Peptide Response Following Bacillus Calmette-Guerin Vaccination in Elderly Individuals.

作者信息

Pandiarajan Arul Nancy, Kumar Nathella Pavan, Rajamanickam Anuradha, Bhavani Perumal Kannabiran, Jeyadeepa Bharathi, Selvaraj Nandhini, Asokan Dinesh, Tripathy Srikanth, Padmapriyadarsini Chandrasekharan, Babu Subash

机构信息

International Center for Excellence in Research, NIAID, Chennai 600031, India.

ICMR-National Institute for Research in Tuberculosis, Chennai 600031, India.

出版信息

Vaccines (Basel). 2024 Sep 18;12(9):1065. doi: 10.3390/vaccines12091065.

DOI:10.3390/vaccines12091065
PMID:39340094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11436028/
Abstract

BACKGROUND

Antimicrobial peptides are an important component of host defense against Mycobacterium tuberculosis. However, the ability of BCG to induce AMPs as part of its mechanism of action has not been investigated in detail.

METHODS

We investigated the impact of Bacillus Calmette-Guerin (BCG) vaccination on circulating plasma levels and TB-antigen stimulated plasma levels of AMPs in a healthy elderly population. We assessed the association of AMPs, including Human Beta Defensin 2 (HBD-2), Human Neutrophil Peptide 1-3 (HNP1-3), Granulysin, and Cathelicidin (LL37), in circulating plasma and TB-antigen stimulated plasma (using IGRA supernatants) at baseline (pre-vaccination) and at Month 1 and Month 6 post vaccination.

RESULTS

Post BCG vaccination, both circulating plasma levels and TB-antigen stimulated plasma levels of AMPs significantly increased at Month 1 and Month 6 compared to pre-vaccination levels in the elderly population. However, the association of AMP levels with latent TB (LTB) status did not exhibit statistical significance.

CONCLUSION

Our findings indicate that BCG vaccination is linked to heightened circulating levels of AMPs in the elderly population, which are also TB-antigen-specific. This suggests a potential mechanism underlying the immune effects of BCG in enhancing host defense against TB.

摘要

背景

抗菌肽是宿主抵御结核分枝杆菌的重要组成部分。然而，卡介苗作为其作用机制的一部分诱导抗菌肽的能力尚未得到详细研究。

方法

我们在健康老年人群中研究了卡介苗接种对循环血浆中抗菌肽水平以及结核抗原刺激血浆中抗菌肽水平的影响。我们评估了包括人β-防御素2（HBD-2）、人中性粒细胞肽1-3（HNP1-3）、颗粒溶素和杀菌肽（LL37）在内的抗菌肽在基线（接种前）、接种后第1个月和第6个月时循环血浆和结核抗原刺激血浆（使用IGRA上清液）中的相关性。

结果

与老年人群接种前水平相比，卡介苗接种后，第1个月和第6个月时循环血浆中抗菌肽水平以及结核抗原刺激血浆中抗菌肽水平均显著升高。然而，抗菌肽水平与潜伏性结核（LTB）状态之间的相关性未显示出统计学意义。

结论

我们的研究结果表明，卡介苗接种与老年人群中循环抗菌肽水平升高有关，且这些抗菌肽具有结核抗原特异性。这提示了卡介苗在增强宿主抵御结核的免疫作用中的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/2f77c3e93276/vaccines-12-01065-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/11d4ab8bd453/vaccines-12-01065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/bd1ab8f59efe/vaccines-12-01065-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/f43411a61190/vaccines-12-01065-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/9d5ca3a29692/vaccines-12-01065-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/6c5fb07baf91/vaccines-12-01065-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/2f77c3e93276/vaccines-12-01065-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/11d4ab8bd453/vaccines-12-01065-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/bd1ab8f59efe/vaccines-12-01065-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/f43411a61190/vaccines-12-01065-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/9d5ca3a29692/vaccines-12-01065-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/6c5fb07baf91/vaccines-12-01065-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fbd/11436028/2f77c3e93276/vaccines-12-01065-g006.jpg

相似文献

1
Enhanced Antimicrobial Peptide Response Following Bacillus Calmette-Guerin Vaccination in Elderly Individuals.卡介苗接种后老年个体抗菌肽反应增强
Vaccines (Basel). 2024 Sep 18;12(9):1065. doi: 10.3390/vaccines12091065.
2
Diminished Systemic and Mycobacterial Antigen Specific Anti-microbial Peptide Responses in Low Body Mass Index-Latent Tuberculosis Co-morbidity.低体重指数与潜伏性结核共病时全身及分枝杆菌抗原特异性抗菌肽反应减弱
Front Cell Infect Microbiol. 2020 Apr 28;10:165. doi: 10.3389/fcimb.2020.00165. eCollection 2020.
3
Diminished systemic levels of antimicrobial peptides in tuberculous lymphadenitis and their reversal after anti-tuberculosis treatment.结核性淋巴结炎患者体内抗菌肽水平降低及其抗结核治疗后的逆转。
Tuberculosis (Edinb). 2020 May;122:101934. doi: 10.1016/j.tube.2020.101934. Epub 2020 Apr 1.
4
Heightened circulating levels of antimicrobial peptides in tuberculosis-Diabetes co-morbidity and reversal upon treatment.结核病-糖尿病合并症中循环抗菌肽水平升高及治疗后的逆转。
PLoS One. 2017 Sep 14;12(9):e0184753. doi: 10.1371/journal.pone.0184753. eCollection 2017.
5
The immunotherapeutic effects of recombinant Bacillus Calmette-Guérin resistant to antimicrobial peptides on bladder cancer cells.抗抗菌肽的重组卡介苗的免疫治疗作用对膀胱癌细胞。
Biochem Biophys Res Commun. 2019 Jan 29;509(1):167-174. doi: 10.1016/j.bbrc.2018.12.097. Epub 2018 Dec 20.
6
MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides.MEK抑制通过减少Toll样受体2激活的抗菌肽释放来增强卡介苗对膀胱癌细胞的疗效。
Oncotarget. 2017 May 26;8(32):53168-53179. doi: 10.18632/oncotarget.18230. eCollection 2017 Aug 8.
7
Modelling the effect of discontinuing universal Bacillus Calmette-Guérin vaccination in an intermediate tuberculosis burden setting.模拟在结核病负担中等的环境中停止普遍使用卡介苗接种的效果。
Vaccine. 2018 Sep 18;36(39):5902-5909. doi: 10.1016/j.vaccine.2018.08.019. Epub 2018 Aug 22.
8
Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis.高龄对经空气感染结核分枝杆菌的豚鼠接种卡介苗的影响。
Clin Vaccine Immunol. 2010 Oct;17(10):1500-6. doi: 10.1128/CVI.00190-10. Epub 2010 Aug 4.
9
Peptide microarray-based characterization of antibody responses to host proteins after bacille Calmette-Guérin vaccination.基于肽微阵列的卡介苗接种后对宿主蛋白抗体反应的表征。
Int J Infect Dis. 2017 Mar;56:140-154. doi: 10.1016/j.ijid.2017.01.027. Epub 2017 Feb 2.
10
Nanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection.由卡介苗工程化的纳米笼促进保护性 Vγ2Vδ2 T 细胞免疫抵抗结核分枝杆菌感染。
J Nanobiotechnology. 2022 Jan 15;20(1):36. doi: 10.1186/s12951-021-01234-3.

本文引用的文献

1
Bacillus Calmette-Guérin (BCG) Revaccination and Protection Against Tuberculosis: A Systematic Review.卡介苗（BCG）再接种与结核病预防：一项系统评价
Cureus. 2024 Mar 21;16(3):e56643. doi: 10.7759/cureus.56643. eCollection 2024 Mar.
2
cell-wall and antimicrobial peptides: a mission impossible?细胞壁与抗菌肽：Mission Impossible？
Front Immunol. 2023 May 17;14:1194923. doi: 10.3389/fimmu.2023.1194923. eCollection 2023.
3
BCG vaccination induces enhanced humoral responses in elderly individuals.卡介苗接种可增强老年人的体液免疫反应。
Tuberculosis (Edinb). 2023 Mar;139:102320. doi: 10.1016/j.tube.2023.102320. Epub 2023 Jan 31.
4
Efficacy of Bacillus Calmette-Guérin (BCG) Vaccination in Reducing the Incidence and Severity of COVID-19 in High-Risk Population (BRIC): a Phase III, Multi-centre, Quadruple-Blind Randomised Control Trial.卡介苗（BCG）接种对降低高危人群（BRIC）中新冠病毒疾病（COVID-19）发病率和严重程度的疗效：一项III期、多中心、四盲随机对照试验
Infect Dis Ther. 2022 Dec;11(6):2205-2217. doi: 10.1007/s40121-022-00703-y. Epub 2022 Oct 15.
5
Role of Antimicrobial Peptides in Treatment and Prevention of Mycobacterium Tuberculosis: A Review.抗菌肽在结核分枝杆菌治疗和预防中的作用：综述
Int J Pept Res Ther. 2022;28(5):132. doi: 10.1007/s10989-022-10435-9. Epub 2022 Jul 22.
6
Tuberculosis in the Elderly.老年人结核病
J Clin Med. 2021 Dec 15;10(24):5888. doi: 10.3390/jcm10245888.
7
BCG vaccination strategies against tuberculosis: updates and perspectives.BCG 疫苗接种策略防治结核病：更新与展望。
Hum Vaccin Immunother. 2021 Dec 2;17(12):5284-5295. doi: 10.1080/21645515.2021.2007711.
8
BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals.BCG 疫苗接种可诱导老年人记忆 T 细胞频率增加和常见 γc 细胞因子的血浆水平改变。
PLoS One. 2021 Nov 10;16(11):e0258743. doi: 10.1371/journal.pone.0258743. eCollection 2021.
9
Effect of BCG vaccination on proinflammatory responses in elderly individuals.BCG 疫苗接种对老年人促炎反应的影响。
Sci Adv. 2021 Aug 4;7(32). doi: 10.1126/sciadv.abg7181. Print 2021 Aug.
10
BCG vaccination induces enhanced frequencies of dendritic cells and altered plasma levels of type I and type III interferons in elderly individuals.BCG 疫苗接种可诱导老年个体中树突状细胞的频率增加，并改变 I 型和 III 型干扰素的血浆水平。
Int J Infect Dis. 2021 Sep;110:98-104. doi: 10.1016/j.ijid.2021.07.041. Epub 2021 Jul 22.