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关于卡介苗对新型冠状病毒肺炎的保护作用:一项综述

On BCG Vaccine Protection from COVID-19: A Review.

作者信息

Bagheri Narges, Montazeri Hesam

机构信息

Department of Applied Mathematics, University of Azarbaijan Shahid Madani, Tabriz, Iran.

Department of Bioinformatics, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.

出版信息

SN Compr Clin Med. 2021;3(6):1261-1271. doi: 10.1007/s42399-021-00835-1. Epub 2021 Mar 15.

DOI:10.1007/s42399-021-00835-1
PMID:33748676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7956872/
Abstract

Bacille Calmette-Guérin (BCG) vaccine has been globally used to protect infants against tuberculosis (TB) for about a century. This vaccine has been shown to provide some degree of non-specific protection from other respiratory tract infections. This advantage has encouraged researchers to investigate the potential protection of this vaccine from the coronavirus disease 2019 from different perspectives in the ongoing pandemic. In this study, we have comprehensively reviewed the latest articles on potential vaccine effectiveness of BCG on COVID-19 and summarized the possible impacts of the BCG against SARS-COV-2 in detail.

摘要

卡介苗(BCG)疫苗在全球范围内用于保护婴儿免受结核病(TB)侵害已有约一个世纪。已证明这种疫苗能提供一定程度的针对其他呼吸道感染的非特异性保护。这一优势促使研究人员在当前大流行中从不同角度研究这种疫苗对2019冠状病毒病的潜在保护作用。在本研究中,我们全面回顾了关于卡介苗对COVID-19潜在疫苗效力的最新文章,并详细总结了卡介苗对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的可能影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27cb/7956872/236e65ea74a2/42399_2021_835_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27cb/7956872/236e65ea74a2/42399_2021_835_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27cb/7956872/236e65ea74a2/42399_2021_835_Fig1_HTML.jpg

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本文引用的文献

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Effectiveness of booster BCG vaccination in preventing Covid-19 infection.BCG 疫苗加强接种预防新冠病毒感染的效果。
Hum Vaccin Immunother. 2021 Nov 2;17(11):3913-3915. doi: 10.1080/21645515.2021.1956228. Epub 2021 Aug 17.
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Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app.COVID-19 症状群:COVID 症状研究应用程序的潜在临床预测工具。
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Recurrent COVID-19 pneumonia in the course of chemotherapy: Consequence of a weakened immune system?
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Front Immunol. 2023 Apr 5;14:1146443. doi: 10.3389/fimmu.2023.1146443. eCollection 2023.
5
BCG and SARS-CoV-2-What Have We Learned?卡介苗与严重急性呼吸综合征冠状病毒2——我们学到了什么?
Vaccines (Basel). 2022 Sep 30;10(10):1641. doi: 10.3390/vaccines10101641.
6
Multiple BCG vaccinations for the prevention of COVID-19 and other infectious diseases in type 1 diabetes.多次接种卡介苗预防 1 型糖尿病患者感染 COVID-19 和其他传染病。
Cell Rep Med. 2022 Sep 20;3(9):100728. doi: 10.1016/j.xcrm.2022.100728. Epub 2022 Aug 15.
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Safety and efficacy of BCG re-vaccination in relation to COVID-19 morbidity in healthcare workers: A double-blind, randomised, controlled, phase 3 trial.卡介苗再接种对医护人员新冠发病率的安全性和有效性:一项双盲、随机、对照、3期试验。
EClinicalMedicine. 2022 Jun;48:101414. doi: 10.1016/j.eclinm.2022.101414. Epub 2022 May 12.
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The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions.结核病和 COVID-19 大流行的交织:人群层面和患者层面的影响、临床表现和纠正干预措施。
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化疗过程中复发性新冠肺炎肺炎:免疫系统减弱的后果?
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PLoS One. 2020 Oct 22;15(10):e0240710. doi: 10.1371/journal.pone.0240710. eCollection 2020.
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PLoS One. 2020 Oct 7;15(10):e0240203. doi: 10.1371/journal.pone.0240203. eCollection 2020.
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Lack of evidence for BCG vaccine protection from severe COVID-19.缺乏卡介苗预防重症新冠病毒肺炎的证据。
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