Zhu Jianhui, Quyyumi Arshed A, Wu Hongsheng, Csako Gyorgy, Rott David, Zalles-Ganley Alexandra, Ogunmakinwa Jibike, Halcox Julian, Epstein Stephen E
Cardiovascular Research Institute, Washington Hospital Center, 108 Irving St NW, GHRB Room 217, Washington, DC 20010, USA.
Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1055-9. doi: 10.1161/01.ATV.0000074899.60898.FD. Epub 2003 May 1.
Previous studies suggest that heat shock protein (HSP) 60 has a contributory role in atherosclerosis development. We examined whether circulating HSP70 protein and anti-HSP70 antibodies are associated with coronary artery disease (CAD).
Blood samples from 421 patients (62% men, mean age 57 years) evaluated for CAD by coronary angiography were tested. Serum HSP70 was detectable in 67% of study subjects with levels ranging from 0.2 to 27.1 ng/mL (mean, 1.08; median, 0.5). HSP70 levels were higher in non-CAD patients than CAD patients (median, 0.72 versus 0.34; P=0.0006). Individuals with HSP70 levels above the median (0.5 ng/mL) had half the risk of CAD than individuals with levels below the median (adjusted odds ratio, 0.52; 95% confidence limit, 0.32 to 0.86). The association of high HSP70 levels with low CAD risk was independent of traditional CAD risk factors (P=0.011). Disease severity (number of diseased vessels) was also inversely associated with HSP70 protein levels (P=0.010). The adjusted odds ratio of having multivessel disease for patients with high HSP70 protein levels was 0.54 (95% confidence limit, 0.36 to 0.81). In contrast, no association between anti-HSP70 IgG seropositivity and the prevalence of CAD was found (P=0.916).
These data provide the first evidence that high levels of human HSP70 are associated with the low CAD risk, probably through its multiple protective effects on a cell's response to stress.
先前的研究表明热休克蛋白（HSP）60在动脉粥样硬化发展中起作用。我们研究了循环中的HSP70蛋白和抗HSP70抗体是否与冠状动脉疾病（CAD）相关。
检测了421例接受冠状动脉造影评估CAD的患者（62%为男性，平均年龄57岁）的血样。67%的研究对象血清中可检测到HSP70，水平范围为0.2至27.1 ng/mL（平均1.08；中位数0.5）。非CAD患者的HSP70水平高于CAD患者（中位数分别为0.72和0.34；P = 0.0006）。HSP70水平高于中位数（0.5 ng/mL）的个体患CAD的风险是水平低于中位数个体的一半（调整后的优势比为0.52；95%置信区间为0.32至0.86）。HSP70高水平与低CAD风险的关联独立于传统的CAD危险因素（P = 0.011）。疾病严重程度（病变血管数量）也与HSP70蛋白水平呈负相关（P = 0.010）。HSP70蛋白水平高的患者发生多支血管病变的调整后优势比为0.54（95%置信区间为0.36至0.81）。相反，未发现抗HSP70 IgG血清阳性与CAD患病率之间存在关联（P = 0.916）。
这些数据首次证明，高水平的人类HSP70与低CAD风险相关，可能是通过其对细胞应激反应的多种保护作用。
