Hambidge Michael
Department of Pediatrics, Section of Nutrition, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
J Nutr. 2003 May;133(5 Suppl 1):1438S-42S. doi: 10.1093/jn/133.5.1438S.
Three selected aspects of human zinc homeostasis and requirements are reviewed with special reference to studies undertaken by the author and his colleagues: 1) the implications for the calculation of physiologic requirements for zinc of the interrelationship between two key variables of zinc homeostasis, intestinal excretion of endogenous zinc and total absorbed zinc, are examined at levels of absorption below those necessary to meet physiologic requirements; 2) a method for deriving average dietary zinc requirements from zinc-stable isotope tracer/metabolic studies is illustrated with examples of studies being conducted in developing countries; and 3) the effect of reduction of high intakes of phytic acid on zinc bioavailability is examined with test meals prepared from low-phytic-acid maize or isohybrid wild-type control maize.
本文特别参考作者及其同事进行的研究，对人类锌稳态和需求的三个选定方面进行了综述：1）在吸收水平低于满足生理需求所需水平时，研究锌稳态的两个关键变量（内源性锌的肠道排泄和总吸收锌）之间的相互关系对锌生理需求计算的影响；2）以在发展中国家进行的研究为例，说明一种从锌稳定同位素示踪/代谢研究中得出平均膳食锌需求的方法；3）用低植酸玉米或等杂交野生型对照玉米制备的试验餐，研究减少高植酸摄入量对锌生物利用度的影响。
