Davidsson Lena
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, CH-8803 Ruschlikon, Switzerland.
J Nutr. 2003 May;133(5 Suppl 1):1560S-2S. doi: 10.1093/jn/133.5.1560S.
The importance of trace element bioavailability in the etiology of nutritional deficiencies, for example in the etiology of iron deficiency and iron deficiency anemia, can be expected to be most pronounced in individuals with high requirements. Of special concern is the situation in poor communities where infants and young children are consuming monotonous, cereal-based diets. Traditionally, cereal-based gruels are often one of the first semisolid foods to be introduced into the infant's diet. These foods can be expected to have low energy and nutrient density as well as low bioavailability of iron due to the presence of phytic acid. Ascorbic acid is a potent enhancer of non-heme iron absorption that can overcome the inhibiting effect of phytic acid when present in high enough quantities. However, home prepared complementary foods based on cereals and legumes contain negligible amounts of ascorbic acid unless ascorbic acid-rich foods are mixed with the cereal or consumed at the same time. Different approaches to improve iron bioavailability from plant-based complementary foods, e.g., by enzymatic degradation of phytic acid and/or by increased consumption of ascorbic acid-rich foods, should be explored and adapted to local conditions. In addition, there is a need to evaluate efficacy and effectiveness of strategies to increase the dietary intake of bioavailable iron by dietary diversification and food fortification under realistic conditions.
微量元素生物利用率在营养缺乏病因学中的重要性,例如在缺铁和缺铁性贫血的病因学中,在需求较高的个体中可能最为明显。特别令人担忧的是贫困社区的情况,那里的婴幼儿食用单调的谷类食物。传统上,谷类糊通常是最早引入婴儿饮食的半固体食物之一。由于植酸的存在,这些食物的能量和营养密度较低,铁的生物利用率也较低。抗坏血酸是一种有效的非血红素铁吸收增强剂,当含量足够高时,可以克服植酸的抑制作用。然而,以谷类和豆类为基础的家庭自制辅食中抗坏血酸含量微乎其微,除非将富含抗坏血酸的食物与谷类混合或同时食用。应探索不同方法来提高植物性辅食中铁的生物利用率,例如通过植酸的酶促降解和/或增加富含抗坏血酸食物的摄入量,并根据当地情况进行调整。此外,有必要在实际条件下评估通过饮食多样化和食物强化来增加生物可利用铁膳食摄入量的策略的功效和效果。